000 04755nam a22004815i 4500
001 978-94-007-6803-1
003 DE-He213
005 20140220082944.0
007 cr nn 008mamaa
008 130828s2013 ne | s |||| 0|eng d
020 _a9789400768031
_9978-94-007-6803-1
024 7 _a10.1007/978-94-007-6803-1
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aProkop, Aleš.
_eeditor.
245 1 0 _aSystems Biology
_h[electronic resource] :
_bIntegrative Biology and Simulation Tools /
_cedited by Aleš Prokop, Béla Csukás.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aXXXI, 553 p. 105 illus., 53 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aFunctional genomics, proteomics, metabolomics and bioinformatics for systems biology -- Comparing biological networks: a survey on graph classifying techniques -- Emergent properties of gene regulatory networks – models and data -- Regulatory crosstalk analysis of biochemical networks in the nucleus accumbens -- Properties of biological networks -- Network analysis for systems biology -- Computational approaches for reconstruction of time-varying biological networks from Omics data -- Probabilistic graphical modeling in systems biology: a framework for integrative approaches -- Innovations of the rule-based modeling approach -- Reproducibility of model-based results in systems biology -- Parameter identifiability and redundancy, with applications to a general class of stochastic carcinogenesis models -- Semantic systems biology: formal knowledge representation in systems biology for model construction, retrieval, validation and discovery -- Computational infrastructures for data and knowledge management in systems biology -- Computational tools and resources for integrative modeling in systems biology -- Agent-based modeling approaches to multi-scale systems biology: An example agent-based model of acute pulmonary inflammation -- Reconstructing cellular signaling and regulatory networks - an integrative approach for systems-level drug discovery -- A survey of current integrative network algorithms for systems biology -- Direct Computer Mapping based modeling of a multiscale process, involving p53/miR-34a signaling.
520 _aGrowth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.
650 0 _aMedicine.
650 0 _aComputer simulation.
650 0 _aMicrobial genetics.
650 0 _aBiomedical engineering.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aMicrobial Genetics and Genomics.
650 2 4 _aSimulation and Modeling.
650 2 4 _aBiomedical Engineering.
700 1 _aCsukás, Béla.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400768024
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-6803-1
912 _aZDB-2-SBL
999 _c99973
_d99973