000 02765nam a22005055i 4500
001 978-94-007-5943-5
003 DE-He213
005 20140220082940.0
007 cr nn 008mamaa
008 130109s2013 ne | s |||| 0|eng d
020 _a9789400759435
_9978-94-007-5943-5
024 7 _a10.1007/978-94-007-5943-5
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aMalyshev, Igor.
_eauthor.
245 1 0 _aImmunity, Tumors and Aging: The Role of HSP70
_h[electronic resource] /
_cby Igor Malyshev.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aXI, 141 p. 48 illus., 46 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringerBriefs in Biochemistry and Molecular Biology,
_x2211-9353 ;
_v6
505 0 _aForward -- Introduction -- 1 A General Description of HSPs, The Molecular Structure of HSP70, The HSP70 Cycle -- 2 HSP70 Functions In Normal Cells -- 3 HSP70 IN A Damaged Cells -- 4 Mechanisms Of Activation And Inactivation Of HSP70 Synthesis -- 5 HSP70 In The Immune Responses -- 6 HSP70 in Carcinogenesis -- 7 HSP70 In Aging -- 8 The Role Of HSP70 in Protection of (a) The Brain In Alzheimer’s Disease, and (b) The Heart -- Index.
520 _aThe book is dedicated to the topical area of biology and medicine and the role of stress proteins HSP70 in the regulation of intracellular protein homeostasis, signaling transduction and cell protection. The book is divided into chapters, which describe the discovery of HSP70 and its molecular structure, the mechanism of the synthesis and function in normal and damaged cells, examine the role of HSP70 in immunity, cancerogenesis, aging, Alzheimer's disease and cardiosurgery. In this book, the author looks at HSP70 as a factor which prevents the transformation of homeostasis mechanisms of intracellular proteins into a link in the pathogenesis of a disease.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aImmunology.
650 0 _aBiochemistry.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aImmunology.
650 2 4 _aProtein Science.
650 2 4 _aMolecular Medicine.
650 2 4 _aCancer Research.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400759428
830 0 _aSpringerBriefs in Biochemistry and Molecular Biology,
_x2211-9353 ;
_v6
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-5943-5
912 _aZDB-2-SBL
999 _c99763
_d99763