000			04754nam a22005055i 4500
001			978-94-007-5940-4
003			DE-He213
005			20140220082940.0
007			cr nn 008mamaa
008			130321s2013 ne | s |||| 0|eng d
020			_a9789400759404 _9978-94-007-5940-4
024	7		_a10.1007/978-94-007-5940-4 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aDougan, David A. _eeditor.
245	1	0	_aRegulated Proteolysis in Microorganisms _h[electronic resource] / _cedited by David A. Dougan.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013.
300			_aXIV, 333 p. 65 illus., 62 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSubcellular Biochemistry, _x0306-0225 ; _v66
505	0		_aMachines of destruction - AAA+ proteases and the adaptors that control them -- The AAA+ protease Lon -- FtsH protease-mediated regulation of various cellular functions -- Regulated proteolysis in Bacillus subtilis -- Regulation of stress response pathways in Escherichia coli by proteolysis -- Regulation of the SigmaE stress response -- Pathogenic bacteria: protein degradation and virulence -- Roles of Cdc48 in regulated protein degradation in yeast -- The role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis & activity control -- PUPylation and Mycobacteria -- Archea proteasomes and SAMPylation.
520			_aThis book contains an extensive collection of critical reviews, from leading researchers in the field of regulated protein degradation. It covers the role of regulated proteolysis in a range of microorganisms (from Gram positive, Gram negative and pathogenic bacteria to Archaea and the Baker’s yeast Saccharomyces cerevisiae).     For many years, intracellular protein degradation was almost exclusively thought of as a non-selective mechanism to recycle amino acids and remove trash from the cell. The contemporary view however, is that protein degradation is a highly selective process that plays a key role in a number of important cellular processes. Not only does it contribute to the maintenance of protein homeostasis (proteostasis) through the direct recognition and removal of damaged proteins, but it also regulates the cells response to a variety of environmental stress signals. Regulatory proteolysis also plays an important role in virulence of pathogenic bacteria, and “fitness” of eukaryotic organelles. This book focuses on the central players in these diverse cellular processes – the AAA+ proteases – and examines how these machines achieve their exquisite specificity. It also highlights the various mechanisms microorganisms use to post-translationally modify their proteins, as a means to regulate protein levels and hence cell physiology.       Regulated proteolysis in microorganisms is a must read for researchers working on protein homeostasis, stress response pathways and virulence. It provides a detailed overview of the components and signals that contribute to the metabolic stability of a protein in various microorganisms. As such, it also forms a useful resource for researchers in biotechnology. The book is essential reading for senior undergraduate and postgraduate students, studying all areas of protein science including protein chemistry, biochemistry, molecular biology, microbiology and biotechnology.     Key features and content:   ·           Molecular mechanism of action of AAA+ proteases ·           Control of substrate specificity by adaptor proteins ·           Post-translational tagging of proteins as a means to control their metabolic stability (SsrA, Ubiquitlyation, PUPylation and SAMPylation) ·           Regulation of stress response pathways by proteolysis ·           Regulated degradation and virulence ·           Protein degradation within mitochondria
650		0	_aMedicine.
650		0	_aScience (General).
650		0	_aBiochemistry.
650		0	_aMicrobiology.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aMicrobiology.
650	2	4	_aProtein Structure.
650	2	4	_aProtein Science.
650	2	4	_aScience, general.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400759398
830		0	_aSubcellular Biochemistry, _x0306-0225 ; _v66
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-5940-4
912			_aZDB-2-SBL
999			_c99762 _d99762