000 03132nam a22004815i 4500
001 978-94-007-5881-0
003 DE-He213
005 20140220082939.0
007 cr nn 008mamaa
008 130217s2013 ne | s |||| 0|eng d
020 _a9789400758810
_9978-94-007-5881-0
024 7 _a10.1007/978-94-007-5881-0
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aDey, Aparajita.
_eeditor.
245 1 0 _aCytochrome P450 2E1: Its Role in Disease and Drug Metabolism
_h[electronic resource] /
_cedited by Aparajita Dey.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aXVI, 256 p. 35 illus., 5 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v67
505 0 _aCytochrome P450 2E1 and its clinical aspects -- Nrf2 and antioxidant defense against CYP2E1 toxicity -- The role of Cytochrome P-4502E1 in ethanol-mediated carcinogenesis -- The Importance of CYP2E1 in the pathogenesis of alcoholic liver disease and drug toxicity and the role of the proteasome -- Relevance of CYP2E1 to non-alcoholic fatty liver disease -- CYP2E1-catalyzed alcohol metabolism -- CYP2E1, oxidative stress, post-translational modifications and  lipid metabolism -- The role of CYP2E1 in alcohol metabolism and sensitivity in the central nervous system.
520 _aThe book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1), which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities, which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of the central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.
650 0 _aMedicine.
650 0 _aToxicology.
650 0 _aLife sciences.
650 0 _aBiochemistry.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aLife Sciences, general.
650 2 4 _aBiochemistry, general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400758803
830 0 _aSubcellular Biochemistry,
_x0306-0225 ;
_v67
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-5881-0
912 _aZDB-2-SBL
999 _c99743
_d99743