000 05036nam a22004815i 4500
001 978-94-007-5866-7
003 DE-He213
005 20140220082939.0
007 cr nn 008mamaa
008 130321s2013 ne | s |||| 0|eng d
020 _a9789400758667
_9978-94-007-5866-7
024 7 _a10.1007/978-94-007-5866-7
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aMandel, Silvia.
_eeditor.
245 1 0 _aNeurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future
_h[electronic resource] /
_cedited by Silvia Mandel.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aXVII, 396 p. 39 illus., 32 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Predictive, Preventive and Personalised Medicine,
_x2211-3495 ;
_v2
505 0 _a1. What is this book series about?- 2. Preface -- 3. Introductory chapter -- 4. Individual predispositions in healthy vasospastic individuals: Patient profiling for targeted prevention of “down-stream” pathologies as cost-effective personalised medicine -- 5. Idiopathic REM sleep behavior disorder as a long-term predictor of neurodegenerative disorders -- 6. New animal models of progressive neurodegeneration: tools for developing predictive diagnostics and identifying presymptomatic therapeutic targets -- 7. Tau pathology: A selected view on the current status -- 8. The Use of Biomarkers for Prediction and Prevention of Alzheimer's and Parkinson's Diseases -- 9. Making clinical trials of Alzheimer’s disease delay-of-onset a reality by use of a prognostic genetic biomarker -- 10. An update on CSF biomarkers of Parkinson’s disease -- 11. Glaucomatous optic neuropathy: Risk assessment and potential targets for effective prevention and treatments tailored to the patient -- 12. Toward a personalized approach in amyotrophic lateral sclerosis: new developments in diagnosis, genetics, pathogenesis and therapies -- 13. Recent advances in ALS research: perspectives for personalized clinical application -- 14. Exercise in Multiple Sclerosis – an Integral Component of Disease Management -- 15. Bridging the Informatics Gap between Bench and Bedside: Implications to Neurodegenerative Diseases -- 16. Personalized Medicine In Rare Paediatric Neurometabolic Diseases.
520 _aThe economic burden of dementia was estimated as being US$ 604 billion in 2010. Now it is time for new guidelines in handling of neurodegenerative disorders. Optimistic versus Pessimistic Prognosis depends much on diagnostic and treatment approaches which healthcare will preferably adopt in the near future. Current dramatic situation can be significantly improved by the implementation of appropriate early diagnostic, targeted preventive measures and therapies tailored to the person advancing healthcare and enhancing the patient life quality. Neurodegenerative Diseases are pathologies of multi-factorial nature involving interplay of epi/genetic and environmental risk factors. Insights into molecular pathomechanisms will enable to create the most effective neuro-protective strategies and individualised treatment before manifest pathology. Utilization of the advanced integrative medical approach could enable a significant portion of population to reach the 100-year age limit remaining vibrant in excellent physical and mental health as actively contributing members of the society. The crucial role of the integrative approach by PPPM has been acknowledged as priorities by World Health Organization, United Nations and the European Union among others. Extensive efforts of international consortia are essential in the field to consolidate the accumulated expertise and to create population screening, robust diagnostic approaches, effective prevention in groups at high risk and targeted treatments. This book volume "Neurodegenerative Diseases: Integrative PPPM Approach as the Medicine of the Future" is intended to serve as a reference source for basic researchers and healthcare industry involved in the field of neurosciences with a special emphasis on mental health promotion and innovations intended to delay or even prevent neurodegenerative diseases.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aNeurology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aHealth Promotion and Disease Prevention.
650 2 4 _aNeurology.
650 2 4 _aNeurosciences.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400758650
830 0 _aAdvances in Predictive, Preventive and Personalised Medicine,
_x2211-3495 ;
_v2
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-5866-7
912 _aZDB-2-SME
999 _c99739
_d99739