000			03586nam a22004815i 4500
001			978-94-007-5842-1
003			DE-He213
005			20140220082939.0
007			cr nn 008mamaa
008			130217s2013 ne | s |||| 0|eng d
020			_a9789400758421 _9978-94-007-5842-1
024	7		_a10.1007/978-94-007-5842-1 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aPfeffer, Ulrich. _eeditor.
245	1	0	_aCancer Genomics _h[electronic resource] : _bMolecular Classification, Prognosis and Response Prediction / _cedited by Ulrich Pfeffer.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013.
300			_aVI, 588 p. 65 illus., 61 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPreface -- Genomic Pathology of Lung Cancer -- Understanding Melanoma Progression by Gene Expression Signatures -- Prognostic testing in uveal melanoma -- Capturing and Deciphering the Molecular Signatures of Head and Neck Cancer -- Predictive and Prognostic Biomarkers for Colorectal Cancer -- Expression Profiling of Hepatocellular Carcinoma -- Kidney Cancer Genomics: Paving the Road to a New Paradigm of Personalized Medicine -- 8 Pancreatic cancer genomics -- Breast Cancer Genomics: From Portraits to Landscapes -- Genomic landscape of ovarian cancer -- Genetics of Endometrial Carcinoma -- Usefulness of molecular biology in follicular-derived thyroid tumors - From translationnal research to clinical practice -- Sarcomas Genetics: From point mutation to complex karyotype, from diagnosis to therapies -- Novel molecular acquisitions in leukemias -- Where do we stand in the genomics of lymphomas?- The Genomics of Multiple Myeloma and Its Relevance in the Molecular Classification and Risk Stratification of the Disease -- Index.
520			_aThe combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with  its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first  ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aGene expression.
650		0	_aDNA microarrays.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aGene Expression.
650	2	4	_aMicroarrays.
650	2	4	_aMolecular Medicine.
650	2	4	_aBiomedicine general.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400758414
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-5842-1
912			_aZDB-2-SBL
999			_c99732 _d99732