000			03292nam a22005295i 4500
001			978-94-007-5808-7
003			DE-He213
005			20140220082939.0
007			cr nn 008mamaa
008			130125s2013 ne | s |||| 0|eng d
020			_a9789400758087 _9978-94-007-5808-7
024	7		_a10.1007/978-94-007-5808-7 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aTucker, Kerry L. _eeditor.
245	1	0	_aCilia and Nervous System Development and Function _h[electronic resource] / _cedited by Kerry L. Tucker, Tamara Caspary.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013.
300			_aXIII, 277 p. 69 illus., 38 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction -- 1 Primary and motile cilia: their ultrastructure and ciliogenesis -- 2 Primary Cilia, Sonic Hedgehog Signaling, and Spinal Cord Development -- 3 Primary cilia and brain development -- 4 Primary Cilia in Cerebral Cortex: Growth and Functions on Neuronal and Non-Neuronal Cells -- 5 Primary Cilia and Inner Ear Sensory Epithelia -- 6 Neuronal Cilia and Obesity -- 7 Motile cilia and brain function: ependymal motile cilia development, organization, function and their associated pathologies -- 8 Primary Cilia and Brain Cancer -- 9 Abnormalities of the Central Nervous System across the Ciliopathy Spectrum.
520			_aCilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as "antennae" for neurons to sense and  process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aHuman physiology.
650		0	_aNeurosciences.
650		0	_aDevelopmental biology.
650		0	_aNeurobiology.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aNeurobiology.
650	2	4	_aNeurosciences.
650	2	4	_aHuman Physiology.
650	2	4	_aCancer Research.
650	2	4	_aDevelopmental Biology.
700	1		_aCaspary, Tamara. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400758070
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-5808-7
912			_aZDB-2-SBL
999			_c99722 _d99722