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001 978-94-007-4719-7
003 DE-He213
005 20140220082934.0
007 cr nn 008mamaa
008 120809s2013 ne | s |||| 0|eng d
020 _a9789400747197
_9978-94-007-4719-7
024 7 _a10.1007/978-94-007-4719-7
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aBarańska, Jolanta.
_eeditor.
245 1 0 _aGlioma Signaling
_h[electronic resource] /
_cedited by Jolanta Barańska.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aX, 227 p. 39 illus., 27 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v986
520 _aGliomas, developing in the brain from the transformed glial cells, are a very special kind of tumors, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. Glioma Signaling is a text reference on cellular signaling processes regulating gliomas physiology and invasiveness. The first half of the book is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides. The remaining chapters deal with the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration, cellular growth, progression and invasion, as well as presents perspectives concerning potential targets for glioma therapy.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aNeurosciences.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aCancer Research.
650 2 4 _aNeurosciences.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400747180
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v986
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-4719-7
912 _aZDB-2-SBL
999 _c99457
_d99457