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001 978-94-007-4667-1
003 DE-He213
005 20140220082934.0
007 cr nn 008mamaa
008 130411s2013 ne | s |||| 0|eng d
020 _a9789400746671
_9978-94-007-4667-1
024 7 _a10.1007/978-94-007-4667-1
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aMacario, Alberto J.L.
_eauthor.
245 1 4 _aThe Chaperonopathies
_h[electronic resource] :
_bDiseases with Defective Molecular Chaperones /
_cby Alberto J.L. Macario, Everly Conway de Macario, Francesco Cappello.
264 1 _aDordrecht :
_bSpringer Netherlands :
_bImprint: Springer,
_c2013.
300 _aXVI, 116 p. 26 illus., 23 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringerBriefs in Biochemistry and Molecular Biology,
_x2211-9353
505 0 _aOverview and book plan -- Chaperones: General characteristics and classifications -- The chaperonopathies: classification, mechanisms, structural features -- Structural and hereditary chaperonopathies: mutation -- Other genetic chaperonopathies -- Acquired chaperonopathies -- Other types of chaperonopathies -- Impact of chaperonopathies in protein homeostasis and beyond -- Extracellular chaperones.
520 _aMemory lapses and occasional incoherent behavior, or intestinal cramps with diarrhea, or protracted cough with low fever, or cardiovascular syndromes, or changes in the pattern of movement of the lower limps, can be signs of an incipient chaperonopathy. Yet many physicians do not know this. Most health care professionals are unfamiliar with chaperonopathies. Clinicians do not look for them because they are unaware of them. Pathologists and clinical biochemists are unprepared to test specimens to detect chaperonopathies. Despite the large amount of information available in the literature, textbooks tend to ignore chaperonopathies. Because of the lack of systematic information in textbooks and courses, chaperonopathies are invisible to practitioners and clinical researchers. This book aims to correct this situation by providing pertinent information in an orderly manner so as to prompt the reader to look for chaperonopathies in patients and seek more information about them. The book serves as an alert signal and as a primer.
650 0 _aMedicine.
650 0 _aBiochemistry.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aBiochemistry, general.
650 2 4 _aProtein Science.
700 1 _aConway de Macario, Everly.
_eauthor.
700 1 _aCappello, Francesco.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9789400746664
830 0 _aSpringerBriefs in Biochemistry and Molecular Biology,
_x2211-9353
856 4 0 _uhttp://dx.doi.org/10.1007/978-94-007-4667-1
912 _aZDB-2-SBL
999 _c99447
_d99447