000			03382nam a22005175i 4500
001			978-94-007-4596-4
003			DE-He213
005			20140220082934.0
007			cr nn 008mamaa
008			120813s2013 ne | s |||| 0|eng d
020			_a9789400745964 _9978-94-007-4596-4
024	7		_a10.1007/978-94-007-4596-4 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aStrasser, Andrea. _eauthor.
245	1	0	_aModelling of GPCRs _h[electronic resource] : _bA Practical Handbook / _cby Andrea Strasser, Hans-Joachim Wittmann.
264		1	_aDordrecht : _bSpringer Netherlands : _bImprint: Springer, _c2013.
300			_aIX, 218 p. 116 illus., 49 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPreface -- 1. Introduction -- 2. G Protein Coupled Receptors -- 3. Sequence alignment and homology modelling -- 4. Construction of ligands -- 5. Lipids -- 6. Minimization and molecular dynamics.- 7. Calculation of Gibbs energy of salvation -- 8. Special topics in GPCR research -- 9. Force fields -- 10. Thermodynamics of ligand-receptor interaction -- 11. Important LINUX commands -- Literature -- Appendix -- Index.
520			_aG protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is – in order to understand the ligand-receptor interactions and functionality of GPCRs on molecular level - an important tool. The book “Modelling of GPCRs – a practical handbook” is focussed onto a practical introduction into molecular modelling of GPCRs. This book is very useful for beginners in GPCR modelling, but also addresses the advanced GPCR modeller: On the one hand, the book introduces  principles of GPCR modelling, including extensive examples. On the other hand, detailed outlooks onto advanced GPCR modelling techniques are presented. Furthermore, the book includes important data, like information about crystal structures in a summarized manner or amino acid sequences, which are essential for GPCR modelling in general. Due to an increase in efficacy and data handling most modellers use LINUX as operating system. To address this, a summary of most important LINUX commands with examples is presented within the book.
650		0	_aMedicine.
650		0	_aBiochemistry.
650		0	_aComputer simulation.
650		0	_aBioinformatics.
650		0	_aBiology _xData processing.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aComputational Biology/Bioinformatics.
650	2	4	_aComputer Appl. in Life Sciences.
650	2	4	_aBioinformatics.
650	2	4	_aSimulation and Modeling.
650	2	4	_aMedicinal Chemistry.
700	1		_aWittmann, Hans-Joachim. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9789400745957
856	4	0	_uhttp://dx.doi.org/10.1007/978-94-007-4596-4
912			_aZDB-2-SBL
999			_c99436 _d99436