000 04407nam a22004815i 4500
001 978-4-431-54409-8
003 DE-He213
005 20140220082927.0
007 cr nn 008mamaa
008 130619s2013 ja | s |||| 0|eng d
020 _a9784431544098
_9978-4-431-54409-8
024 7 _a10.1007/978-4-431-54409-8
_2doi
050 4 _aQR185.8.C95
072 7 _aPSF
_2bicssc
072 7 _aSCI007000
_2bisacsh
072 7 _aSCI017000
_2bisacsh
082 0 4 _a572.6
_223
100 1 _aMoustakas, Aristidis.
_eeditor.
245 1 0 _aTGF-β in Human Disease
_h[electronic resource] /
_cedited by Aristidis Moustakas, Keiji Miyazawa.
264 1 _aTokyo :
_bSpringer Japan :
_bImprint: Springer,
_c2013.
300 _aVIII, 464 p. 39 illus., 32 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart I Introduction -- 1 Transforming Growth Factor-β Signaling -- 2 TGF-β Signaling in Stem Cell Fate Determination -- 3 Emerging Roles of TGF-β Co-receptors in Human Disease -- Part II Cancer, Fibrosis, and Inflammation -- 4 TGF-β in Cancer Stem Cells -- 5 TGF-β as Tumor Suppressor: In Vitro Mechanistic Aspects of Growth Inhibition -- 6 TGF-β as Tumor Suppressor: Lessons from Mouse Models -- 7 The Multifunctional Roles of TGF-β in Navigating the Metastatic Cascade -- 8 TGF-β Signaling in Leukemogenesis -- 9 TGF-β in Skin Cancer and Fibrosis -- 10 The Role of TGF-β in Cutaneous Melanoma Biology -- 11 The Transforming Growth Factor-Beta (TGF-β) in Liver Fibrosis -- 12 TGF-β and Inhibitory Smads in Inflammation -- Part III Cardiovascular Diseases -- 13 TGF-β and Cardiovascular Disorders -- 14 TGF-β Signaling in Physiological and Pathological Angiogenesis -- 15 TGF-β Signaling Pathway and MicroRNAs in Cardiovascular Disease -- Part IV Other Diseases -- 16 TGF-β and Genetic Skeletal Diseases -- 17 TGF-β in Brain Disorders -- 18 TGF-β and Metabolic Homeostasis -- Part V Disease Prognosis and Therapy. 19 Targeting Pro-Angiogenic TGF-β Signaling in the Tumor Microenvironment.
520 _aTransforming growth factor-β (TGF-β) is a secreted polypeptide with multifunctional properties manifested during embryonic development, adult organ physiology, and pathobiology of major diseases, including cancer and fibrotic and cardiovascular diseases. The signaling pathway of TGF-β now is rather well understood. Continuing revelations in the mechanisms of action of TGF-β provide specific mechanistic examples of how human cells lose their controlled function and behave wrongly during the development of diverse diseases. Equally important, however, is the current promise of exploiting the TGF-β pathway in combating human disease. This book comprehensively covers major areas of human disease where the involvement of TGF-β is firmly established. Simultaneously, the book highlights major gaps in knowledge and the future directions of research that can benefit human medical science. The core set of diseases where TGF-β action is well documented and are included in the book are cancer and cardiovascular and fibrotic disorders. The central aim of the book is to stimulate young scientists to enter the prolific TGF-β field and find new solutions to the problems remaining in this area of study. For this purpose the book provides authoritative educational chapters that furnish a good introduction to the field for young doctoral students, postdocs, and clinical fellows. The book also serves as a valuable reference for the aficionados in the field, who can find accessible and well-illustrated material for their teaching and lecturing activities, via which the importance of TGF-β biology is disseminated to the world of science and to the public.
650 0 _aLife sciences.
650 0 _aOncology.
650 0 _aCytokines.
650 0 _aCytology.
650 1 4 _aLife Sciences.
650 2 4 _aCytokines and Growth Factors.
650 2 4 _aCell Biology.
650 2 4 _aCancer Research.
700 1 _aMiyazawa, Keiji.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9784431544081
856 4 0 _uhttp://dx.doi.org/10.1007/978-4-431-54409-8
912 _aZDB-2-SBL
999 _c99089
_d99089