000 04228nam a22005655i 4500
001 978-3-7091-1511-4
003 DE-He213
005 20140220082926.0
007 cr nn 008mamaa
008 130407s2013 au | s |||| 0|eng d
020 _a9783709115114
_9978-3-7091-1511-4
024 7 _a10.1007/978-3-7091-1511-4
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aGulbins, Erich.
_eeditor.
245 1 0 _aSphingolipids in Disease
_h[electronic resource] /
_cedited by Erich Gulbins, Irina Petrache.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2013.
300 _aVIII, 478 p. 38 illus., 33 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v216
505 0 _aSphingolipids in Cancer: Sphingosine Kinase / Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance -- Using ASMase knockout Mice to Model Human Diseases -- New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer -- Sphingolipids and Response to Chemotherapy -- Lung Cancer and Lung Injury: The Dual Role of Ceramide -- Sphingolipids Role in Radiotherapy for Prostate Cancer -- Sphingolipids in Cardio-Reno-vascular diseases: Sphingolipid Metabolism and Atherosclerosis -- Cardiovascular Effects of Sphingosine-1-Phosphate S1P -- Cross-Talk between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease -- Sphingolipids in Inflammation, Infection and Lung Diseases -- Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity -- Sphingolipids in Acute Lung Injury -- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases -- Ceramide in Cystic Fibrosis.- Regulation of the Sphingosine Kinase/Sphingosine 1 Phosphate Pathway -- Bacterial Infections and Ceramide -- Viral Infections and Sphingolipids -- Ceramide in Plasma Membrane Repair -- Sphingolipids and Inflammatory Diseases of the Skin -- Sphingolipids in Diabetes -- Sphingolipids in Neuro-psychiatry and Muscle Diseases: Neuronal Forms of Gaucher Disease -- Sphingolipids in Neuroinflammation -- Sphingolipids in Psychiatric Disorders and Pain Syndromes -- Role of Sphingosine-1-Phosphate in Sceletal Muscle Cell Biology.
520 _aSphingolipids are lipid components of the plasma membrane of eukaryotic cells with an important function in signaling mechanisms in the cell. This  book provides insight into the physiological and pathophysiological role of sphingolipids and in particular its derivative ceramide. The function of Sphingolipids in cell signaling with regard to infectious and lung diseases, cancer, cardiovascular diseases and neuropsychiatric disorders are described and treated in distinct parts. Together with Volume 215 from the same Editors, the collection represents a unique, comprehensive work on Sphingolipids, providing information on both: Sphingolipid basic biology  as well as its important function in a (patho)physiological context. The book is written for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians in pharmacology, oncology, cardiology, neurology and infectious disease.   
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aImmunology.
650 0 _aNeurosciences.
650 0 _aToxicology.
650 0 _aCardiology.
650 0 _aLipids.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aCardiology.
650 2 4 _aCancer Research.
650 2 4 _aImmunology.
650 2 4 _aNeurosciences.
650 2 4 _aLipidology.
700 1 _aPetrache, Irina.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783709115107
830 0 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v216
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-7091-1511-4
912 _aZDB-2-SBL
999 _c98989
_d98989