000			03589nam a22004695i 4500
001			978-3-7091-1410-0
003			DE-He213
005			20140220082926.0
007			cr nn 008mamaa
008			130622s2013 au | s |||| 0|eng d
020			_a9783709114100 _9978-3-7091-1410-0
024	7		_a10.1007/978-3-7091-1410-0 _2doi
050		4	_aQD431-431.7
072		7	_aPSBC _2bicssc
072		7	_aSCI007000 _2bisacsh
082	0	4	_a572.633 _223
100	1		_aJakubowski, Hieronim. _eauthor.
245	1	0	_aHomocysteine in Protein Structure/Function and Human Disease _h[electronic resource] : _bChemical Biology of Homocysteine-containing Proteins / _cby Hieronim Jakubowski.
264		1	_aVienna : _bSpringer Vienna : _bImprint: Springer, _c2013.
300			_aXIII, 166 p. 49 illus., 9 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_a1. Introduction -- 2. Homocysteine. Chemical Synthesis -- Physicochemical Properties -- Quantification Methods -- Metabolic Pathways -- Clinical significance -- 3. Homocysteine Thiolactone -- Chemical Synthesis -- Physicochemical Properties -- Quantification Methods -- Biological Formation and Turnover -- Clinical Significance -- 4. N-Homocysteinylated Proteins -- Functional Consequences -- Albumin -- Fibrinogen -- Cytochrome c -- Other Proteins -- Quantification Methods -- Total N-homocysteinylation assays -- Site-specific N-homocysteinylation assays -- Formation in vivo -- Turnover to Nε-Homocysteinyl-lysine -- Biological Consequences and Clinical Significance -- 5. S-Homocysteinylated Proteins -- Formation in vitro -- Functional Consequences -- Annexin -- Metallothionein -- Fibrilin, Fibronectin, Tropoelastin -- Detection in vivo -- Biological consequences -- Conclusions -- References.
520			_aExcess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
650		0	_aLife sciences.
650		0	_aMetabolic diseases.
650		0	_aBiochemistry.
650	1	4	_aLife Sciences.
650	2	4	_aProtein Structure.
650	2	4	_aProtein Science.
650	2	4	_aBiochemistry, general.
650	2	4	_aMedical Biochemistry.
650	2	4	_aMetabolic Diseases.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783709114094
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-7091-1410-0
912			_aZDB-2-SBL
999			_c98980 _d98980