000 03686nam a22004695i 4500
001 978-3-7091-1325-7
003 DE-He213
005 20140220082925.0
007 cr nn 008mamaa
008 121213s2013 au | s |||| 0|eng d
020 _a9783709113257
_9978-3-7091-1325-7
024 7 _a10.1007/978-3-7091-1325-7
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aHrckova, Gabriela.
_eauthor.
245 1 0 _aPharmacological Potential of Selected Natural Compounds in the Control of Parasitic Diseases
_h[electronic resource] /
_cby Gabriela Hrckova, Samuel Velebny.
264 1 _aVienna :
_bSpringer Vienna :
_bImprint: Springer,
_c2013.
300 _aXI, 125 p. 19 illus., 8 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringerBriefs in Pharmaceutical Science & Drug Development,
_x1864-8118
505 0 _aProtozoan infections, pathology and therapy -- Current antiprotozoan drugs and problem of resistance -- Natural compounds with direct antiprotozoal activity -- Natural compounds isolated from higher plants -- Bioactive compounds from lower terrestrial organisms -- Marine organisms – undiscovered source of the potential drugs -- Concluding remarks -- Parasitic helminthes of human and amimals: health impact and control -- Anthelmintic drugs – efficacy, side effects and resistance -- Natural compounds with direct anthelmintic activity -- Anthelmintic potential of higher plants -- Lower terrestrial and marine organisms in anthelmintic drug discovery -- Concluding remarks -- Combined therapy of parasitic infections using substances from natural sources -- Host pathology and immunosuppression during parasitic infections -- Natural compounds with immunomodulatory effects -- Natural compounds with antioxidant and other host-protecting activities -- Summary: perpectives and possibilities in drug discovery from natural sources.
520 _aThe natural world with a large number of terrestrial and marine plants and lower organisms is a great source of bioactive compounds historically used as remedies in various diseases. Within the last decade, such compounds became more attractive targets for pharmacologists and the pharmaceutical industry in drug development projects. This volume presents the pharmacological potential of chemically defined natural compounds obtained from plants, fungi, algae and cyanobacteria with antiparasitic activity, that have been tested against various endo-parasitic protozoan and helminth species. Additionally, the advantages of combined therapy using antiparasitic drugs and natural compounds with selected specific activity are reviewed and explained in the context of host pathology and immunosuppression induced by the parasites. The conclusions of this new book give suggestions for further non-empirical drug development and discuss perspectives of alternative approaches to therapy of parasitic diseases.
650 0 _aMedicine.
650 0 _aMedical parasitology.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aParasitology.
700 1 _aVelebny, Samuel.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783709113240
830 0 _aSpringerBriefs in Pharmaceutical Science & Drug Development,
_x1864-8118
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-7091-1325-7
912 _aZDB-2-SME
999 _c98968
_d98968