000 02876nam a22005055i 4500
001 978-3-642-40717-8
003 DE-He213
005 20140220082919.0
007 cr nn 008mamaa
008 131218s2013 gw | s |||| 0|eng d
020 _a9783642407178
_9978-3-642-40717-8
024 7 _a10.1007/978-3-642-40717-8
_2doi
050 4 _aR857.M3
072 7 _aTGM
_2bicssc
072 7 _aTCB
_2bicssc
072 7 _aTEC021000
_2bisacsh
072 7 _aSCI009000
_2bisacsh
082 0 4 _a620.11
_223
100 1 _aKim, Hae Won.
_eeditor.
245 1 0 _aHemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics
_h[electronic resource] /
_cedited by Hae Won Kim, A. Gerson Greenburg.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aXXIII, 746 p. 130 illus., 77 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aBrief historical account of HBOC development -- Physiology of respiration -- Oxygen transport to tissues -- Pathophysiology of acute anemia -- Global blood safety and need for safe blood supply -- Blood transfusion and its limitations -- Scientific basis and design of HBOCs -- HBOCs: a regulatory perspective -- Current HBOC products in development -- Clinical indications and clinical trials of HBOCs -- HBOCs and adverse events observed in clinical trials -- HBOC-mediated vasoactivity and hypertension -- HBOC and oxygen and nitrogen radical mediated toxicity -- HBOCs and clinical laboratory interference -- Animal models for HBOC studies -- New emerging Technologies for universal RBCs -- Future prospects.
520 _aCurrently, hemoglobin (Hb)-based oxygen carriers (HBOCs) are leading candidates as red blood cell substitutes. In addition, HBOCs are also potential oxygen therapeutics for treatment of patients with critical ischemic conditions due to atherosclerosis, diabetes and other conditions. This book will provide readers a comprehensive review of topics involved in the HBOC development. It focusses on current products and clinical applications as well as on emerging technologies and future prospects.
650 0 _aMedicine.
650 0 _aBiochemistry.
650 0 _aHematology.
650 0 _aBiomaterials.
650 1 4 _aMaterials Science.
650 2 4 _aBiomaterials.
650 2 4 _aMolecular Medicine.
650 2 4 _aMedicinal Chemistry.
650 2 4 _aHematology.
700 1 _aGreenburg, A. Gerson.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642407161
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-40717-8
912 _aZDB-2-CMS
999 _c98653
_d98653