000 04341nam a22005415i 4500
001 978-3-642-38919-1
003 DE-He213
005 20140220082913.0
007 cr nn 008mamaa
008 131220s2013 gw | s |||| 0|eng d
020 _a9783642389191
_9978-3-642-38919-1
024 7 _a10.1007/978-3-642-38919-1
_2doi
050 4 _aQR355-502
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9101
_223
100 1 _aAnderson, Larry J.
_eeditor.
245 1 0 _aChallenges and Opportunities for Respiratory Syncytial Virus Vaccines
_h[electronic resource] /
_cedited by Larry J. Anderson, Barney S. Graham.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aXI, 409 p. 38 illus., 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v372
505 0 _aRespiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease -- Clinical and Epidemiologic Features of Respiratory Syncytial Virus -- Influence of Respiratory Syncytial Virus Strain Differences on Pathogenesis and Immunity -- Structure and Function of Respiratory Syncytial Virus Surface Glycoproteins -- Respiratory Syncytial Virus and Reactive Airway Disease -- Human Genetics and Respiratory Syncytial Virus Disease: Current Findings and Future Approaches -- Innate Immune Responses to Respiratory Syncytial Virus Infection -- The Adaptive Immune Response to Respiratory Syncytial Virus -- Respiratory Syncytial Virus Mechanisms to Interfere with Type 1 Interferons -- Host Gene Expression and Respiratory Syncytial Virus Infection -- Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus -- Respiratory Syncytial Virus Disease:  Prevention and Treatment -- Live-Attenuated Respiratory Syncytial Virus Vaccines -- Subunit and Virus-Like Particle Vaccine Approaches for Respiratory Syncytial Virus -- Gene-Based Vaccine Approaches for Respiratory Syncytial Virus -- Bovine Model of Respiratory Syncytial Virus Infection -- The Cotton Rat S. hispidus Model of Respiratory Syncytial Virus Infection -- The Mouse Model of Respiratory Syncytial Virus Disease -- Human Airway Epithelial Cell Cultures for Modeling Respiratory Syncytial Virus Infection -- Challenges and Opportunities for Respiratory Syncytial Virus Vaccines.
520 _aAlthough respiratory syncytial virus (RSV) has been a high priority for vaccine development for over 50 years now, still no vaccine is available and none has yet demonstrated sufficient promise to move to licensure. The success of RSV immune prophylaxis and the availability of ever more powerful tools to study the immune response and pathogenesis of disease, combined with the ability to construct a wide variety of vaccines using different vaccine platforms, give us grounds to believe that an RSV vaccine is within reach. This book brings together in one source what is currently known about the virus: its clinical and epidemiologic features; the host response and pathogenesis of the disease; vaccines, vaccine platforms, and treatment; and animal and tissue culture models of RSV infection. It is designed to organize the critical information relevant to RSV vaccine development, facilitate the assimilation of data, and speed progress toward producing a safe and effective vaccine.
650 0 _aMedicine.
650 0 _aVaccines.
650 0 _aMedical virology.
650 0 _aEmerging infectious diseases.
650 0 _aPneumology.
650 0 _aPediatrics.
650 1 4 _aBiomedicine.
650 2 4 _aVirology.
650 2 4 _aVaccine.
650 2 4 _aInfectious Diseases.
650 2 4 _aPneumology/Respiratory System.
650 2 4 _aPediatrics.
700 1 _aGraham, Barney S.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642389184
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v372
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-38919-1
912 _aZDB-2-SBL
999 _c98361
_d98361