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001 978-3-642-38664-0
003 DE-He213
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008 131004s2013 gw | s |||| 0|eng d
020 _a9783642386640
_9978-3-642-38664-0
024 7 _a10.1007/978-3-642-38664-0
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aHumbert, Marc.
_eeditor.
245 1 0 _aPharmacotherapy of Pulmonary Hypertension
_h[electronic resource] /
_cedited by Marc Humbert, Oleg V. Evgenov, Johannes-Peter Stasch.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aIX, 576 p. 66 illus., 56 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v218
505 0 _aPreface.- Part I. Pulmonary hypertension: conceptual bases of the disease. Pulmonary hypertension: definition, classification, and epidemiology. Pulmonary hypertension: pathophysiology and signalling pathways. Pulmonary hypertension: pathology. Pulmonary hypertension: biomarkers. Pulmonary hypertension: animal models -- Part II. Pulmonary hypertension: established therapies. General supportive care. Calcium channel blockers. Prostacyclins. Endothelin receptor antagonists. Phosphodiesterase 5 inhibitors -- Part III. Pulmonary hypertension: novel pathways and emerging therapies     Soluble guanylate cyclase stimulators. Therapeutics targeting dysregulated redox equilibrium and endothelial dysfunction (NOXs, sGC activators, GSNOR). Rho-kinase inhibitors. Serotonin transporters and serotonin receptors. PDGF inhibitors. Novel anti-proliferative strategies beyond imatinib. Immunosuppressive agents. Vasoactive peptides. Inhibitors of cGMP/cAMP metabolism (MRP4, MRP5, PDE1). Old targets re-visited. Stem cells and cell based therapy -- Part IV. Conclusions and Outlook. Pulmonary hypertension: evidence-based management in the modern era and future directions.
650 0 _aMedicine.
650 0 _aMedical laboratories.
650 0 _aToxicology.
650 0 _aPharmaceutical technology.
650 0 _aInternal medicine.
650 0 _aPneumology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aPharmaceutical Sciences/Technology.
650 2 4 _aInternal Medicine.
650 2 4 _aPneumology/Respiratory System.
650 2 4 _aLaboratory Medicine.
650 2 4 _aMolecular Medicine.
700 1 _aEvgenov, Oleg V.
_eeditor.
700 1 _aStasch, Johannes-Peter.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642386633
830 0 _aHandbook of Experimental Pharmacology,
_x0171-2004 ;
_v218
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-38664-0
912 _aZDB-2-SBL
999 _c98307
_d98307