000 02783nam a22004095i 4500
001 978-3-642-37999-4
003 DE-He213
005 20140220082910.0
007 cr nn 008mamaa
008 130703s2013 gw | s |||| 0|eng d
020 _a9783642379994
_9978-3-642-37999-4
024 7 _a10.1007/978-3-642-37999-4
_2doi
050 4 _aQD415-436
072 7 _aPNN
_2bicssc
072 7 _aSCI013040
_2bisacsh
082 0 4 _a547
_223
100 1 _aMangani, Stefano.
_eeditor.
245 1 0 _aDisruption of Protein-Protein Interfaces
_h[electronic resource] :
_bIn Search of New Inhibitors /
_cedited by Stefano Mangani.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aVII, 161 p. 55 illus., 35 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aDrug discovery by targeting protein-protein interactions -- Protein-Protein Interaction Inhibitors: case studies on small molecules and natural compounds -- Disrupting Protein-Protein Interfaces using GRID Molecular Interaction Fields -- NMR as a tool to target protein-protein interactions -- Protein-protein interactions in the solid state The troubles of crystallizing of protein- protein complexes -- Fluorescence observables and enzyme kinetics in the investigation of PPI modulation by small molecules Detection, mechanistic insight, functional consequences.
520 _a"Disruption of Protein-Protein Interfaces" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces, as well as including details of experimental and computational tools to tackle the subject, and highlighting the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs. Consequently, in recent years great effort has been dedicated to unveiling the molecular details of protein-protein interfaces by structural techniques e.g. X-ray diffraction, NMR spectroscopy. This book, written and edited by leaders in the field, provides examples from the literature of successes and failures to develop drug-like molecules effective in interacting at protein-protein interfaces.
650 0 _aChemistry.
650 0 _aChemistry, Organic.
650 1 4 _aChemistry.
650 2 4 _aOrganic Chemistry.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642379987
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-37999-4
912 _aZDB-2-CMS
999 _c98176
_d98176