000 03297nam a22005415i 4500
001 978-3-642-37765-5
003 DE-He213
005 20140220082909.0
007 cr nn 008mamaa
008 130518s2013 gw | s |||| 0|eng d
020 _a9783642377655
_9978-3-642-37765-5
024 7 _a10.1007/978-3-642-37765-5
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
100 1 _aCullen, Bryan R.
_eeditor.
245 1 0 _aIntrinsic Immunity
_h[electronic resource] /
_cedited by Bryan R. Cullen.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aVII, 262 p. 23 illus., 22 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v371
505 0 _aThe APOBEC3 Family of Retroelement Restriction Factors -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family -- The Antiviral Activities of Tetherin -- Restriction of Retroviral Infection of Macrophages -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response.
520 _aRecent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.  
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aMedical virology.
650 0 _aMicrobial genetics.
650 0 _aPlant diseases.
650 0 _aInvertebrates.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aVirology.
650 2 4 _aMicrobial Genetics and Genomics.
650 2 4 _aMolecular Medicine.
650 2 4 _aPlant Pathology.
650 2 4 _aInvertebrates.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642377648
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v371
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-37765-5
912 _aZDB-2-SBL
999 _c98146
_d98146