000 04175nam a22005175i 4500
001 978-3-642-36827-1
003 DE-He213
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007 cr nn 008mamaa
008 130514s2013 gw | s |||| 0|eng d
020 _a9783642368271
_9978-3-642-36827-1
024 7 _a10.1007/978-3-642-36827-1
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
100 1 _aJirtle, Randy L.
_eeditor.
245 1 0 _aEnvironmental Epigenomics in Health and Disease
_h[electronic resource] :
_bEpigenetics and Complex Diseases /
_cedited by Randy L. Jirtle, Frederick L. Tyson.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aXIV, 339 p. 26 illus., 16 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aEpigenetics and Human Health,
_x2191-2262
505 0 _aPreface -- Epigenetic programming of the brain -- Epigenetics and maternal brain evolution -- Social environment and DNA methylation:  A mechanism for linking nurture and nature -- Sex differences in epigenetic programming of brain differentiation: Implications for mental health and disease -- Epigenetics and neurological disorders -- Phenotypic plasticity, pleiotropy, and the growth-first theory of imprinting -- The imprinted brain: How genes set the balance between autism and psychosis -- Epigenetics at the interface of genetics and environmental factors in autism -- Epigenomic and non-coding  RNA regulation in addictive processes -- Epigenetic therapies in neurological diseases -- Epigenetics, nutrition, diabetes, and obesity -- Nutrition, histone epigenetic marks, and disease -- Chromatin switching and gene dynamics associated with type 2 diabetes -- Developmental epigenetic programming in diabetes and obesity -- Epigenetics and cancer -- Developmental reprogramming by environmental estrogens: How early life exposures affect cancer risk in adulthood.- Human cancer epigenetics -- Epigenetics and the law -- Legal and ethical implications of epigenetics -- Subject index. .
520 _aThe capacity of the epigenome to interpret both internal and external stimuli and alter expression programs is a critical component in normal development, aging, and disease pathogenesis. In the past decade, we have witnessed an explosion of unprecedented research on and support for epigenetics, epigenomics, and their interface with human health and disease. In this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, a number of leading investigators in the field of epigenetics discuss patterns of epigenomic modifications in normal cells, and how environmentally-induced changes in them are associated with disease pathogenesis. The authors comprehensively review the epigenetic adaptations that occur in human embryonic stem cells, as well as in differentiating cells and organs such as the brain when exposed to environmental factors, and discuss the legal and ethical implications of such alterations. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic programming.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aHuman genetics.
650 0 _aNeurosciences.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aCancer Research.
650 2 4 _aNeurosciences.
700 1 _aTyson, Frederick L.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642368264
830 0 _aEpigenetics and Human Health,
_x2191-2262
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-36827-1
912 _aZDB-2-SBL
999 _c97970
_d97970