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001 978-3-642-33570-9
003 DE-He213
005 20140220082855.0
007 cr nn 008mamaa
008 121214s2013 gw | s |||| 0|eng d
020 _a9783642335709
_9978-3-642-33570-9
024 7 _a10.1007/978-3-642-33570-9
_2doi
050 4 _aRM1-950
072 7 _aMMG
_2bicssc
072 7 _aMED071000
_2bisacsh
082 0 4 _a615
_223
100 1 _aRummel, Andreas.
_eeditor.
245 1 0 _aBotulinum Neurotoxins
_h[electronic resource] /
_cedited by Andreas Rummel, Thomas Binz.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aX, 321 p. 48 illus., 39 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v364
520 _aBotulinum neurotoxins are the most toxic natural substances and represent a major threat to the population when intentionally released in bioterrorist attacks. On the other hand, during the past two decades botulinum neurotoxins have become established as indispensable drugs for the treatment of a variety of severe neurological disorders. The need for efficient countermeasures as well as the expansion into additional fields of therapeutic application, call for comprehensive information on the botulinum neurotoxin molecules and their mode of action. Our knowledge of this subject has made great strides in recent years, setting the stage for the development of new botulinum neurotoxin-based molecules and novel applications. This book reviews the current status of basic botulinum neurotoxin research. The first part describes the genetic variability of the toxin-producing bacteria, and sheds light on each step from toxin ingestion to the abrogation of synaptic signaling including the intestinal passage and absorption, nerve cell binding and entry, and intracellular substrate cleavage. The remaining chapters detail progress made in detection methods for botulinum neurotoxins, the development of botulinum neurotoxin inhibitors, and strategies to refine the neurotoxins for further medicinal applications by means of recombinant technologies.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aToxicology.
650 1 4 _aBiomedicine.
650 2 4 _aPharmacology/Toxicology.
650 2 4 _aNeurosciences.
700 1 _aBinz, Thomas.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642335693
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v364
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-33570-9
912 _aZDB-2-SBL
999 _c97391
_d97391