| 000 | 02629nam a22004815i 4500 | ||
|---|---|---|---|
| 001 | 978-3-642-32051-4 | ||
| 003 | DE-He213 | ||
| 005 | 20140220082851.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 120829s2013 gw | s |||| 0|eng d | ||
| 020 |
_a9783642320514 _9978-3-642-32051-4 |
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| 024 | 7 |
_a10.1007/978-3-642-32051-4 _2doi |
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| 050 | 4 | _aQD415-436 | |
| 072 | 7 |
_aPNN _2bicssc |
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| 072 | 7 |
_aSCI013040 _2bisacsh |
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| 082 | 0 | 4 |
_a547 _223 |
| 100 | 1 |
_aHutchby, Marc. _eauthor. |
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| 245 | 1 | 0 |
_aNovel Synthetic Chemistry of Ureas and Amides _h[electronic resource] / _cby Marc Hutchby. |
| 264 | 1 |
_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2013. |
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| 300 |
_aXVII, 166 p. 358 illus., 41 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053 |
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| 505 | 0 | _aTransition metal catalysis -- Palladium catalysis -- Pd(II) catalysed aminocarbonylation of alkenes -- Carbonylation of aryl ureas -- Urea Hydrolysis -- Amide hydrolysis. | |
| 520 | _aIn this thesis, the author investigates the chemistry and application of molecules containing urea and amide bonds. These bonds are some of the strongest known and are fundamental to biological processes. The author describes his discovery that sterically hindered ureas undergo solvolysis at room temperature under neutral conditions. This is a remarkable finding, since ureas are inert under these conditions and a general rule of chemistry is that hindered substrates are less reactive. Remarkably, the author translates these results to the correspondingly sterically hindered amides. This thesis has resulted in a number of outstanding publications in high profile journals. The unique method for breaking urea and amide bonds developed in this study is likely to have far reaching consequences for biological protein manipulation. | ||
| 650 | 0 | _aChemistry. | |
| 650 | 0 | _aChemistry, Organic. | |
| 650 | 0 | _aCatalysis. | |
| 650 | 0 | _aBiochemistry. | |
| 650 | 1 | 4 | _aChemistry. |
| 650 | 2 | 4 | _aOrganic Chemistry. |
| 650 | 2 | 4 | _aCatalysis. |
| 650 | 2 | 4 | _aProtein Science. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9783642320507 |
| 830 | 0 |
_aSpringer Theses, Recognizing Outstanding Ph.D. Research, _x2190-5053 |
|
| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-3-642-32051-4 |
| 912 | _aZDB-2-CMS | ||
| 999 |
_c97187 _d97187 |
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