000 03477nam a22005415i 4500
001 978-3-642-30331-9
003 DE-He213
005 20140220082848.0
007 cr nn 008mamaa
008 120814s2013 gw | s |||| 0|eng d
020 _a9783642303319
_9978-3-642-30331-9
024 7 _a10.1007/978-3-642-30331-9
_2doi
050 4 _aRC254-282
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a616.994
_223
100 1 _aChan, Andrew T.
_eeditor.
245 1 0 _aProspects for Chemoprevention of Colorectal Neoplasia
_h[electronic resource] :
_bEmerging Role of Anti-Inflammatory Drugs /
_cedited by Andrew T. Chan, Elmar Detering.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aVIII, 183 p. 29 illus., 18 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aRecent Results in Cancer Research,
_x0080-0015 ;
_v191
505 0 _aWhat is chemoprevention today?- Mechanistic aspects in tumor development and progression of colorectal adenoma and carcinoma -- Mode of action of  aspirin as a chemopreventive agent -- Coxibs: pharmacology, toxicity and efficacy in cancer clinical trials -- COX-2 active agents in chemoprevention (includes aspirin, coxibs, and DFMO) -- New potential developments in aspirin/NSAID derivatives -- Aspirin in CRC chemoprevention in the context of other chronic diseases -- Nutritional agents with anti-inflammatory properties in chemoprevention of colorectal adenoma and carcinoma -- Genetic risks for CRC and hereditary forms of CRC. – Strategies for prevention in high risk population.
520 _aThe prevention of colorectal cancer is a subject of increasing medical importance, and there have been a number of promising recent developments. This book examines in detail important aspects of the current status and future prospects for chemoprevention of colorectal tumors. Research into the mechanisms that lead from early colorectal adenoma to colorectal cancer is discussed. The role and modes of action of available drugs such as celecoxib and sulindac are described, and recent data from aspirin trials are analyzed. In addition, the possible impact of nutritional agents with anti-inflammatory properties is considered, and strategies applicable in those with a high level of genetic risk are evaluated. An important feature of the book is its holistic perspective, making it relevant for gastroenterologists, internists, general practitioners, oncologists, colorectal and gastroenterological surgeons, and public health practitioners.
650 0 _aMedicine.
650 0 _aInternal medicine.
650 0 _aCardiology.
650 0 _aGastroenterology.
650 0 _aOncology.
650 0 _aColon (Anatomy)
_xSurgery.
650 1 4 _aMedicine & Public Health.
650 2 4 _aOncology.
650 2 4 _aGastroenterology.
650 2 4 _aInternal Medicine.
650 2 4 _aCardiology.
650 2 4 _aColorectal Surgery.
700 1 _aDetering, Elmar.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642303302
830 0 _aRecent Results in Cancer Research,
_x0080-0015 ;
_v191
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-30331-9
912 _aZDB-2-SME
999 _c96990
_d96990