000 03328nam a22005055i 4500
001 978-3-642-27340-7
003 DE-He213
005 20140220082845.0
007 cr nn 008mamaa
008 130321s2013 gw | s |||| 0|eng d
020 _a9783642273407
_9978-3-642-27340-7
024 7 _a10.1007/978-3-642-27340-7
_2doi
050 4 _aQR355-502
072 7 _aMMFM
_2bicssc
072 7 _aMED052000
_2bisacsh
082 0 4 _a616.9101
_223
100 1 _aBartenschlager, Ralf.
_eeditor.
245 1 0 _aHepatitis C Virus: From Molecular Virology to Antiviral Therapy
_h[electronic resource] /
_cedited by Ralf Bartenschlager.
264 1 _aBerlin, Heidelberg :
_bSpringer Berlin Heidelberg :
_bImprint: Springer,
_c2013.
300 _aVIII, 346 p. 34 illus., 20 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v369
505 0 _aThe Origin of Hepatitis C Virus -- Cell Culture Systems for Hepatitis C Virus -- Animal Models for Hepatitis C -- Hepatitis C Virus Entry -- Hepatitis C Virus Proteins: From Structure to Function -- Hepatitis C Virus RNA Translation -- Hepatitis C Virus RNA Replication -- Virion Assembly and Release -- Innate Immune Responses to Hepatitis C Virus -- Adaptive Immune Responses in Hepatitis C Virus Infection -- Liver Injury and Disease Pathogenesis in Chronic Hepatitis C -- Hepatitis C Virus-Specific Directly Acting Antiviral Drugs -- Treatment of Chronic Hepatitis C: Current and Future.
520 _aHepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aDrug interactions.
650 0 _aMedical virology.
650 0 _aClinical medicine.
650 1 4 _aBiomedicine.
650 2 4 _aVirology.
650 2 4 _aImmunology.
650 2 4 _aDrug Resistance.
650 2 4 _aHepatology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783642273391
830 0 _aCurrent Topics in Microbiology and Immunology,
_x0070-217X ;
_v369
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-642-27340-7
912 _aZDB-2-SBL
999 _c96820
_d96820