000			02898nam a22005055i 4500
001			978-3-642-23380-7
003			DE-He213
005			20140220082845.0
007			cr nn 008mamaa
008			130517s2013 gw | s |||| 0|eng d
020			_a9783642233807 _9978-3-642-23380-7
024	7		_a10.1007/978-3-642-23380-7 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
100	1		_aJirtle, Randy L. _eeditor.
245	1	0	_aEnvironmental Epigenomics in Health and Disease _h[electronic resource] : _bEpigenetics and Disease Origins / _cedited by Randy L Jirtle, Frederick L. Tyson.
264		1	_aBerlin, Heidelberg : _bSpringer Berlin Heidelberg : _bImprint: Springer, _c2013.
300			_aXV, 302 p. 41 illus., 34 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aEpigenetics and Human Health, _x2191-2262
520			_aExposure to environmental toxicants is associated with changes in DNA methylation and gene expression profiles that together can contribute to increased disease susceptibility. The chapters in this volume, Environmental Epigenomics in Health and Disease - Epigenetics and Disease Origins, address a wide range of environmental exposures, such as airborne particulates, cocaine, radiation, tobacco smoke, and xenoestrogens. Particular emphasis is placed on the consequences of environmental exposures during development on epigenetic reprogramming that influences adult disease pathogenesis. Health outcomes associated with these exposures include autoimmune disorders, neurodevelopmental disorders, and cancer. Importantly, dietary supplements and drugs can modify the epigenetic effects induced by these agents, thereby reducing their toxicological impact. The overall purpose of this volume and its companion, Environmental Epigenomics in Health and Disease - Epigenetics and Complex Diseases, is to give readers an overview of how environmental exposures during early development can influence disease formation by disrupting epigenetic processes and developmental programming.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aHuman genetics.
650		0	_aMedical genetics.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aCancer Research.
650	2	4	_aGene Function.
700	1		_aTyson, Frederick L. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783642233791
830		0	_aEpigenetics and Human Health, _x2191-2262
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-642-23380-7
912			_aZDB-2-SBL
999			_c96792 _d96792