000 02867nam a22004695i 4500
001 978-3-319-00702-1
003 DE-He213
005 20140220082839.0
007 cr nn 008mamaa
008 130809s2013 gw | s |||| 0|eng d
020 _a9783319007021
_9978-3-319-00702-1
024 7 _a10.1007/978-3-319-00702-1
_2doi
050 4 _aQD410-412.5
072 7 _aPNND
_2bicssc
072 7 _aSCI013040
_2bisacsh
082 0 4 _a547.05
_223
100 1 _aEscribano Cuesta, Ana.
_eauthor.
245 1 0 _aNew Gold-Catalyzed Reactions and Applications for the Synthesis of Alkaloids
_h[electronic resource] /
_cby Ana Escribano Cuesta.
264 1 _aCham :
_bSpringer International Publishing :
_bImprint: Springer,
_c2013.
300 _aXIII, 195 p. 280 illus., 41 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
505 0 _aIntroduction -- General Objectives -- Gold(I)-Catalyzed Reactions of 1,6-Enynes with Aldehydes: Cycloaddition versus Metathesis-Type Reactions -- Formation of Cyclobutene Compounds via Gold(I)-Catalyzed Cycloisomerization of 1,n-Enynes -- Approach Toward the Total Synthesis of Lundurines.
520 _aAna Escribano Cuesta's thesis presents a detailed study of the inter- and intramolecular reactions of carbonyl compounds with 1,6-enynes using gold (I) complexes. An important part of the work involved streamlining the variables that allow the selective synthesis of different products such as tricyclic compounds, dihydropyrans, 1,3-dienes or cyclobutenes. The second chapter highlights the importance and difficulties in synthesising a cyclobutene subunit and the author includes a detailed description of how the products were prepared. The final chapter outlines the synthesis of lundurines using methodology developed by the author's research group for intramolecular gold-catalyzed cyclization of indoles with alkynes. The lundurine products developed in this work show significant in vitro cytoxicity toward B16 melanoma cells. The work in this thesis has led to a number of publications in high-profile chemistry journals.
650 0 _aChemistry.
650 0 _aChemistry, Organic.
650 0 _aCatalysis.
650 1 4 _aChemistry.
650 2 4 _aOrganometallic Chemistry.
650 2 4 _aCatalysis.
650 2 4 _aOrganic Chemistry.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319007014
830 0 _aSpringer Theses, Recognizing Outstanding Ph.D. Research,
_x2190-5053
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-00702-1
912 _aZDB-2-CMS
999 _c96466
_d96466