000 02772nam a22005295i 4500
001 978-3-319-00303-0
003 DE-He213
005 20140220082837.0
007 cr nn 008mamaa
008 130518s2013 gw | s |||| 0|eng d
020 _a9783319003030
_9978-3-319-00303-0
024 7 _a10.1007/978-3-319-00303-0
_2doi
050 4 _aQR1-502
072 7 _aPSG
_2bicssc
072 7 _aSCI045000
_2bisacsh
082 0 4 _a579
_223
100 1 _aByers, B. Rowe.
_eeditor.
245 1 0 _aIron Acquisition by the Genus Mycobacterium
_h[electronic resource] :
_bHistory, Mechanisms, Role of Siderocalin, Anti-Tuberculosis Drug Development /
_cedited by B. Rowe Byers.
264 1 _aHeidelberg :
_bSpringer International Publishing :
_bImprint: Springer,
_c2013.
300 _aV, 92 p. 39 illus., 9 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringerBriefs in Molecular Science,
_x2191-5407
505 0 _aA History of Iron Metabolism in the Mycobacteria -- Mycobacterial Iron Uptake Mechanisms -- Siderocalin Combats Mycobacterial Infections -- Design of Anti-TB Drugs Using the Iron Uptake Platform.
520 _aIron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described.  The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed.  The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
650 0 _aLife sciences.
650 0 _aChemistry, inorganic.
650 0 _aBioorganic chemistry.
650 0 _aEmerging infectious diseases.
650 0 _aRNA-ligand interactions.
650 0 _aMicrobiology.
650 1 4 _aLife Sciences.
650 2 4 _aMicrobiology.
650 2 4 _aProtein-Ligand Interactions.
650 2 4 _aInorganic Chemistry.
650 2 4 _aBioorganic Chemistry.
650 2 4 _aInfectious Diseases.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783319003023
830 0 _aSpringerBriefs in Molecular Science,
_x2191-5407
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-319-00303-0
912 _aZDB-2-SBL
999 _c96390
_d96390