000			03063nam a22005535i 4500
001			978-3-0348-0679-4
003			DE-He213
005			20140220082836.0
007			cr nn 008mamaa
008			130628s2013 sz | s |||| 0|eng d
020			_a9783034806794 _9978-3-0348-0679-4
024	7		_a10.1007/978-3-0348-0679-4 _2doi
050		4	_aQH432
072		7	_aPSVH _2bicssc
072		7	_aPSAK1 _2bicssc
072		7	_aSCI070000 _2bisacsh
072		7	_aSCI29000 _2bisacsh
082	0	4	_a591.35 _223
100	1		_aBarrett, Lucy W. _eauthor.
245	1	0	_aUntranslated Gene Regions and Other Non-coding Elements _h[electronic resource] : _bRegulation of Eukaryotic Gene Expression / _cby Lucy W. Barrett, Sue Fletcher, Steve D. Wilton.
264		1	_aBasel : _bSpringer Basel : _bImprint: Springer, _c2013.
300			_aVIII, 56 p. 2 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aSpringerBriefs in Biochemistry and Molecular Biology, _x2211-9353
505	0		_aIntroduction -- Promoter -- 5’ Untranslated Region -- Structure -- Intronic Regions -- 3’ Untranslated Region -- Non-coding RNAs -- Conclusion.
520			_aThere is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as “junk DNA”, it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5’ and 3’ untranslated regions and introns. In addition, pervasive transcription of complex genomes produces a variety of non-coding transcripts that interact with these regions and contribute to regulation. This book discusses recent insights into the regulatory roles of the untranslated gene regions and non-coding RNAs in the control of complex gene expression, as well as the implications of this in terms of organism complexity and evolution.
650		0	_aLife sciences.
650		0	_aMedical genetics.
650		0	_aNucleic acids.
650		0	_aPlant breeding.
650		0	_aAnimal genetics.
650	1	4	_aLife Sciences.
650	2	4	_aAnimal Genetics and Genomics.
650	2	4	_aPlant Genetics & Genomics.
650	2	4	_aGene Function.
650	2	4	_aNucleic Acid Chemistry.
700	1		_aFletcher, Sue. _eauthor.
700	1		_aWilton, Steve D. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783034806787
830		0	_aSpringerBriefs in Biochemistry and Molecular Biology, _x2211-9353
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-0348-0679-4
912			_aZDB-2-SBL
999			_c96327 _d96327