000			03505nam a22005175i 4500
001			978-3-0348-0664-0
003			DE-He213
005			20140220082836.0
007			cr nn 008mamaa
008			130723s2013 sz | s |||| 0|eng d
020			_a9783034806640 _9978-3-0348-0664-0
024	7		_a10.1007/978-3-0348-0664-0 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aMaximov, Philipp Y. _eauthor.
245	1	0	_aTamoxifen _h[electronic resource] : _bPioneering Medicine in Breast Cancer / _cby Philipp Y. Maximov, Russell E. McDaniel, V. Craig Jordan.
264		1	_aBasel : _bSpringer Basel : _bImprint: Springer, _c2013.
300			_aXXII, 199 p. 54 illus., 32 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMilestones in Drug Therapy
505	0		_aDiscovery and Pharmacology of Nonsteroidal Estrogens and Antiestrogens -- Tamoxifen Goes Forward Alone -- Metabolites of Tamoxifen as the Basis of Drug Development -- Adjuvant Therapy – The Breakthrough -- The Wisconsin Story in the 1980’s: Discovery of Target Site Specific Estrogen Action -- Carcinogenesis and Tamoxifen -- Chemoprevention: Cinderella waiting for the ball -- Tamoxifen and Raloxifene head to head: The STAR TRIAL -- Acquired resistance to Tamoxifen: back to the beginning -- The legacy of Tamoxifen -- Appendix: Four decades of discovery in breast cancer research and treatment – an interview with V. Craig Jordan by Marc Poirot -- Selected Awards that Recognize the Contribution of Tamoxifen and Raloxifene to Medicine.
520			_aTamoxifen is a pioneering medicine for the treatment and prevention of breast cancer. It is the first drug targeted therapy in cancer to be successful. Tamoxifen targets the tumor estrogen receptor. The therapy is known to have saved the lives of millions of women over the past 40 years. This monograph, written by V. Craig Jordan - known as the “father of tamoxifen” - and his Tamoxifen Team at the Georgetown University Washington DC, illustrates the journey of this milestone in medicine. It includes a personal interview with V. Craig Jordan about his four decades of discovery in breast cancer research and treatment. V. Craig Jordan was there for the birth of tamoxifen as he is credited for reinventing a “failed morning after contraceptive” to become the “gold standard” for the treatment of breast cancer. He contributed to every aspect of tamoxifen application in therapeutics and all aspects of tamoxifen’s pharmacology. He discovered the selective estrogen receptor modulators (SERMs) and explored the new biology of estrogen-induced apoptosis.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aToxicology.
650		0	_aEndocrinology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aPharmacology/Toxicology.
650	2	4	_aOncology.
650	2	4	_aEndocrinology.
700	1		_aMcDaniel, Russell E. _eauthor.
700	1		_aJordan, V. Craig. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9783034806633
830		0	_aMilestones in Drug Therapy
856	4	0	_uhttp://dx.doi.org/10.1007/978-3-0348-0664-0
912			_aZDB-2-SBL
999			_c96326 _d96326