000 04440nam a22005895i 4500
001 978-3-0348-0522-3
003 DE-He213
005 20140220082836.0
007 cr nn 008mamaa
008 121213s2013 sz | s |||| 0|eng d
020 _a9783034805223
_9978-3-0348-0522-3
024 7 _a10.1007/978-3-0348-0522-3
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
100 1 _aQuesniaux, Valérie.
_eeditor.
245 1 0 _aIL-17, IL-22 and Their Producing Cells: Role in Inflammation and Autoimmunity
_h[electronic resource] /
_cedited by Valérie Quesniaux, Bernhard Ryffel, Franco Padova.
250 _a2nd ed. 2013.
264 1 _aBasel :
_bSpringer Basel :
_bImprint: Springer,
_c2013.
300 _aIX, 354 p. 25 illus., 14 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aProgress in Inflammation Research
505 0 _aIL-17A family, receptors, proinflammatory effects and production -- IL-22 and IL-17 overview -- IL-17R family: Structure, signal transduction and function -- Contribution of IL-22 to Th17 responses: repairing and protecting peripheral tissues -- Central role of Th-17 cells in adaptive immune responses -- Regulatory T cells vs Th17: Differentiation of Th17 versus Treg are they mutually exclusive Other sources of IL-17: iNKT cells -- Retinoic acid in mucosal immune regulation -- Critical role of IL-17 in experimental arthritis -- Dual role IL-17A, F and IL-22 in allergic asthma -- Inflammasome - IL-1 - IL-17 response in lung inflammation -- The role of Il-17 in exp autoimmune mycocarditis -- Th17 cells in transplantation: actors or innocent bystanders -- Is IL-17 required to control of tuberculosis IL-17 and mucosal host defense. Role of IL-17 and IL-17 family cytokines on tumor development -- IL-17 and TH17 cells in rheumatoid arthritis and other inflammatory conditions -- Targeting Th17 Cells for therapy of multiple sclerosis -- Involvement of interleukin-17 cytokines in human asthma -- IL-17 and/or IL-22 as potential target(s) for Crohn’s disease -- Role of IL-23, IL-17 and IL-22 in psoriasis -- Contribution of IL-22 to experimental skin inflammation -- Genetic mouse models to investigate IL-17 responses -- IL-17A as a therapeutic target for autoimmune diseases.
520 _aThe knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition “Th17 Cells: Role in Inflammation and Autoimmune Disease” in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed. The role of IL-22 in cutaneous inflammation including psoriasis has been reviewed. In addition, the volume contains critical updates on autoimmunity, organ transplantation, tumor immunology and genetic mouse models for mechanistic studies. Lastly, the latest clinical progress in neutralizing antibodies to IL-17A, IL-17RA not only confirms the therapeutic promise foreseen in 2008, but also improves our knowledge of the pathogenesis of autoimmune diseases. In summary, this is a timely update and important review of the clinical and experimental aspects of IL-17, IL-22 and their producing cells.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aImmunology.
650 0 _aEmerging infectious diseases.
650 0 _aCell receptors.
650 0 _aCytokines.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aCytokines and Growth Factors.
650 2 4 _aReceptors.
650 2 4 _aCell Biology.
650 2 4 _aInfectious Diseases.
650 2 4 _aCancer Research.
700 1 _aRyffel, Bernhard.
_eeditor.
700 1 _aPadova, Franco.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9783034805216
830 0 _aProgress in Inflammation Research
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-0348-0522-3
912 _aZDB-2-SME
999 _c96299
_d96299