000 03127nam a22005295i 4500
001 978-1-4899-8053-3
003 DE-He213
005 20140220082833.0
007 cr nn 008mamaa
008 131213s2013 xxu| s |||| 0|eng d
020 _a9781489980533
_9978-1-4899-8053-3
024 7 _a10.1007/978-1-4899-8053-3
_2doi
050 4 _aQH588.S83
072 7 _aPSAK
_2bicssc
072 7 _aSCI017000
_2bisacsh
072 7 _aSCI049000
_2bisacsh
082 0 4 _a571.6
_223
100 1 _aBrevini, Tiziana A.L.
_eauthor.
245 1 0 _aPluripotency in Domestic Animal Cells
_h[electronic resource] /
_cby Tiziana A.L. Brevini, Fulvio Gandolfi.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aVII, 46 p. 28 illus., 24 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringerBriefs in Stem Cells,
_x2192-8118
505 0 _aEarly Embryo Development in Large Animals -- Syngamy and Spindle Formation -- Cleavage, compaction and blastulation -- Cell commitment -- Naive versus established epiblast -- Pluripotency in Domestic Animal Embryos -- Expression, restriction and interactions of molecules involved in the control of cell potency and commitment -- Species-specific and stage specific pluripotency markers -- Use of Large Animal Models for Regenerative Medicine -- Why do we need stem cell line from large animal species? -- What are the applications and potentials -- What are the limits?.
520 _aThis addition to the Springer Brief in Stem Cells series focuses on aspects related to the specific mechanisms that ensure and control pluripotency and cell commitment in domestic animal species. This topic is generating rapidly-increasing interest due to the great potential for domestic animal species to be used as intermediate biomedical models, between the mouse and the human. The Brief addresses why we need large animal models for regenerative medicine. It also describes early embryo development with a careful and specific analysis of the regulatory mechanisms driving cleavage, polarization and genome activation in domestic species. How pluripotency is compartmentalized in domestic species as well as the different aspects that make the derivation of stem cells in domestic species very difficult are also addressed.
650 0 _aLife sciences.
650 0 _aReproductive Medicine.
650 0 _aCytology.
650 0 _aStem cells.
650 0 _aEmbryology.
650 1 4 _aLife Sciences.
650 2 4 _aStem Cells.
650 2 4 _aEmbryology.
650 2 4 _aCell Biology.
650 2 4 _aReproductive Medicine.
700 1 _aGandolfi, Fulvio.
_eauthor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781489980526
830 0 _aSpringerBriefs in Stem Cells,
_x2192-8118
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4899-8053-3
912 _aZDB-2-SBL
999 _c96125
_d96125