000			02873nam a22004815i 4500
001			978-1-4614-8621-3
003			DE-He213
005			20140220082832.0
007			cr nn 008mamaa
008			130919s2013 xxu| s |||| 0|eng d
020			_a9781461486213 _9978-1-4614-8621-3
024	7		_a10.1007/978-1-4614-8621-3 _2doi
050		4	_aRB155-155.8
050		4	_aQH431
072		7	_aMFN _2bicssc
072		7	_aMED107000 _2bisacsh
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
100	1		_aKhalil, Ahmad M. _eeditor.
245	1	0	_aMolecular Biology of Long Non-coding RNAs _h[electronic resource] / _cedited by Ahmad M. Khalil, Jeff Coller.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aX, 227 p. 28 illus., 18 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPreface -- Chromatin regulation by long non-coding RNAs -- Regulation of Eukaryotic Cell Differentiation by Long Noncoding RNAs -- Roles of long non-coding RNAs in X-chromosome inactivation -- Roles of Long Non-Coding RNAs in Genomic Imprinting -- Dysregulation of long noncoding RNAs in human disease -- Functions of long non-coding RNAs in non-mammalian systems -- Emerging technologies to study long non-coding RNAs -- Long non coding RNAs and nuclear body formation and function -- Index.
520			_aLong non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book consolidates these ideas and models to better examine the most important issues in lncRNA biology. This includes critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.
650		0	_aMedicine.
650		0	_aHuman genetics.
650		0	_aBiochemistry.
650	1	4	_aBiomedicine.
650	2	4	_aHuman Genetics.
650	2	4	_aBiomedicine general.
650	2	4	_aProtein Science.
700	1		_aColler, Jeff. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461486206
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-8621-3
912			_aZDB-2-SBL
999			_c96072 _d96072