000 03547nam a22005175i 4500
001 978-1-4614-8289-5
003 DE-He213
005 20140220082831.0
007 cr nn 008mamaa
008 131008s2013 xxu| s |||| 0|eng d
020 _a9781461482895
_9978-1-4614-8289-5
024 7 _a10.1007/978-1-4614-8289-5
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
072 7 _aSCI029000
_2bisacsh
082 0 4 _a611.01816
_223
100 1 _aLiebermann, Dan A.
_eeditor.
245 1 0 _aGadd45 Stress Sensor Genes
_h[electronic resource] /
_cedited by Dan A. Liebermann, Barbara Hoffman.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aX, 134 p. 18 illus., 11 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v793
505 0 _aGadd45 in stress signaling, cell cycle control and apoptosis -- Gadd45 in Modulation of Solid Tumors and Leukemia -- Gadd45 Proteins: Key players of repair-mediated DNA demethylation -- Gadd45 proteins in Immunity -- Gadd45 in the liver — Signal transduction and transcriptional mechanisms -- The Role of the Gadd45 Family in the Nervous System: A focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics -- Gadd45 stress sensors in preeclampsia -- Index.
520 _aEmerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  
650 0 _aMedicine.
650 0 _aHuman genetics.
650 0 _aMedical genetics.
650 0 _aBiochemistry.
650 1 4 _aBiomedicine.
650 2 4 _aGene Function.
650 2 4 _aBiochemistry, general.
650 2 4 _aHuman Genetics.
700 1 _aHoffman, Barbara.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461482888
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v793
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8289-5
912 _aZDB-2-SBL
999 _c96044
_d96044