000 03827nam a22004695i 4500
001 978-1-4614-8256-7
003 DE-He213
005 20140220082831.0
007 cr nn 008mamaa
008 131004s2013 xxu| s |||| 0|eng d
020 _a9781461482567
_9978-1-4614-8256-7
024 7 _a10.1007/978-1-4614-8256-7
_2doi
050 4 _aRB155-155.8
050 4 _aQH431
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
082 0 4 _a611.01816
_223
082 0 4 _a599.935
_223
100 1 _aD'Amato, Mauro.
_eeditor.
245 1 0 _aMolecular Genetics of Inflammatory Bowel Disease
_h[electronic resource] /
_cedited by Mauro D'Amato, John D Rioux.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXIII, 343 p. 23 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPart 1: The Foundation of IBD Genetics, Human and Animal Studies -- A Primer on IBD: Phenotypes, Diagnosis, Treatment and Clinical Challenges -- Genetic Epidemiology of Inflammatory Bowel Disease, Early Twin and Family Studies -- Insights from Recent Advances in Animal Models of Inflammatory Bowel Disease -- Part Two: The Genetic and Molecular Makeup of Inflammatory Bowel Disease -- Complex Disease Genes and their Discovery -- The Genetics of Crohn's Disease -- Genetics of Ulcerative Colitis -- Genetic Overlap between Inflammatory Bowel Disease and Other Diseases -- Molecular Profiling of IBD Subtypes/Response to Therapy -- Epigenetics of Inflammatory Bowel Disease -- Part 3: Pathogenetic Pathways in Inflammatory Bowel Disease -- Nod1 and Nod2 and the Immune Response to Bacteria -- The IL-23-Th17 Axis in Intestinal Inflammation -- Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics -- The Epithelial Barrier -- Host Interactions with Bacteria: From “Entente Cordiale” to “Casus Belli” -- Cytokines in Inflammatory Bowel Disease -- Part 4: Concluding Remarks and Future Perspectives -- Towards Personalized Therapy in Inflammatory Bowel Disease -- Index.
520 _aInflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn’s disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.
650 0 _aMedicine.
650 0 _aHuman genetics.
650 1 4 _aBiomedicine.
650 2 4 _aHuman Genetics.
650 2 4 _aMolecular Medicine.
650 2 4 _aBiomedicine general.
700 1 _aRioux, John D.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461482550
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8256-7
912 _aZDB-2-SBL
999 _c96040
_d96040