000 03379nam a22004695i 4500
001 978-1-4614-8214-7
003 DE-He213
005 20140220082831.0
007 cr nn 008mamaa
008 131005s2013 xxu| s |||| 0|eng d
020 _a9781461482147
_9978-1-4614-8214-7
024 7 _a10.1007/978-1-4614-8214-7
_2doi
050 4 _aRG133.5
072 7 _aMFKC
_2bicssc
072 7 _aHEA039060
_2bisacsh
082 0 4 _a612.6
_223
100 1 _aKim, S. Samuel.
_eeditor.
245 1 0 _aOocyte Biology in Fertility Preservation
_h[electronic resource] /
_cedited by S. Samuel Kim.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aX, 97 p. 12 illus., 9 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v761
505 0 _aThe importance of oocyte biology for the future of fertility preservation -- The Control of Oocyte Survival by Intrinsic and Extrinsic Factors -- Oocyte Genomic Integrity -- In Vitro Activation of Dormant Follicles for Fertility Preservation -- Primate follicular development in vitro -- Vitrification of oocytes - From Basic Science to Clinical Application -- Memoir of Fertility Preservation.
520 _aFertility preservation has become one of the most important and fast growing fields of reproductive medicine.  Although there are several strategies for fertility preservation in female, most of them are still considered experimental.  It is important to perfect the existing technologies, but also developing new strategies should be actively sought.  The future development of fertility preservation strategies should be based on the sound scientific knowledge and principles.  One of the main objectives of fertility preservation in females is prevention of oocyte depletion. The mechanisms of oocyte loss and survival in the ovary are complex, which include genetic control both in germ cells and in somatic cells, DNA damage and repair mechanism, apoptosis and autophagy, and other poorly understood molecular mechanisms.  To develop clinically effective and safe strategies for fertility preservation, it is essential to know and understand the fundamentals of oocyte and ovarian biology at the molecular level.  Thus, the purpose of this edition is to review the current progress in research related to molecular and genetic control of oocyte development that can be applied to fertility preservation.  The main topics that are discussed in this publication include molecular signaling mechanisms of oocyte activation and loss, genomic integrity of oocytes, and epigenetics.  
650 0 _aMedicine.
650 0 _aReproductive Medicine.
650 0 _aCytology.
650 1 4 _aMedicine & Public Health.
650 2 4 _aReproductive Medicine.
650 2 4 _aCell Biology.
650 2 4 _aMolecular Medicine.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461482130
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v761
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8214-7
912 _aZDB-2-SBL
999 _c96036
_d96036