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001 978-1-4614-8051-8
003 DE-He213
005 20140220082831.0
007 cr nn 008mamaa
008 130906s2013 xxu| s |||| 0|eng d
020 _a9781461480518
_9978-1-4614-8051-8
024 7 _a10.1007/978-1-4614-8051-8
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aMalek, Sami.
_eeditor.
245 1 0 _aAdvances in Chronic Lymphocytic Leukemia
_h[electronic resource] /
_cedited by Sami Malek.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXI, 334 p. 25 illus., 24 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v792
505 0 _aPreface -- B-cell receptor and antigens in CLL -- The CLL cell microenvironment -- Acquired genomic copy number aberrations in CLL -- Recurrent gene mutations in CLL -- TP53 aberrations in CLL -- Gene expression and epigenetic deregulation -- Apoptosis deregulation in CLL -- Richter’s Syndrome -- Molecular biomarkers in chronic lymphocytic leukemia -- Critical Signal Transduction Pathways in CLL -- Immunotherapies in CLL -- Novel therapeutic agents in CLL -- Inherited susceptibility to CLL -- miR deregulations in CLL -- Index.
520 _aChronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. CLL has a highly varied clinical course.  While advances in CLL therapy are noted, many patients still succumb to this illness. Like most progress in medicine, solid advances in the diagnosis, prognosis and treatment of CLL are rooted in an in-depth understanding of the basic and translational biology of CLL.  In this book, CLL experts have contributed state-of-the-art summaries of various important aspects of CLL biology and have discussed the translational implication of such findings.  This book, which is directed at physicians and researchers alike, aims to educate broadly and deeply.  Intentionally, the many aspects and nuances of CLL clinical care that can only really be appreciated through direct patient care are not covered here, but instead, the book presents basic aspects of CLL that underlie many of the contemporary decisions that are made in CLL research and clinical settings. We hope that this book will critically inform the community and stimulate interest in CLL, which will ultimately translate into better CLL research, prognostication and therapy, with the end goal of providing a better outlook for patients afflicted with this common leukemia. 
650 0 _aMedicine.
650 0 _aOncology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461480501
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v792
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8051-8
912 _aZDB-2-SBL
999 _c96025
_d96025