000 04284nam a22004815i 4500
001 978-1-4614-8008-2
003 DE-He213
005 20140220082831.0
007 cr nn 008mamaa
008 130814s2013 xxu| s |||| 0|eng d
020 _a9781461480082
_9978-1-4614-8008-2
024 7 _a10.1007/978-1-4614-8008-2
_2doi
050 4 _aQH301-705
072 7 _aPSA
_2bicssc
072 7 _aSCI086000
_2bisacsh
072 7 _aSCI064000
_2bisacsh
082 0 4 _a570
_223
100 1 _aVodovotz, Yoram.
_eeditor.
245 1 0 _aComplex Systems and Computational Biology Approaches to Acute Inflammation
_h[electronic resource] /
_cedited by Yoram Vodovotz, Gary An.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXI, 291 p. 54 illus., 29 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aAn overview of the Translational Dilemma and the need for Translational Systems Biology of inflammation -- Part I: Complex Systems Methods and Applications -- Translational Equation-based Modeling -- Agent-based Modeling in Translational Systems Biology -- Analysis of Heart Rate Variability -- Analysis of Ventilatory Pattern Variability -- Part II: Translational Modeling of Sepsis and Trauma -- Disorder of Systemic Inflammation in Sepsis and Trauma: A Systems Perspective -- Multi-scale equation-based models: Insights for Inflammation and Physiological Variability -- Integrating Data Driven and Mechanistic Models of the Inflammatory Response in Sepsis and Trauma -- In silico Trials and Personalized Therapy for Sepsis and Trauma -- Part III: Translational Modeling of Wound Healing -- Disorder of Localized Inflammation in Wound Healing: A Systems Perspective -- Equation-based Models of Wound Healing and Collective Cell Migration -- Agent-based Models of Wound Healing -- Part IV: Translational Modeling of Host-pathogen Interactions -- Modeling Host-Pathogen Interactions in Necrotizing Enterocolitis -- Modeling Host-Vector-Pathogen Immuno-inflammatory Interactions in Malaria -- Part V: Future Perspectives -- Translation to Implementation -- The Rationale and Implementation of Translational Systems Biology as a new Paradigm for the Study of Inflammation -- Index.
520 _aThe Translational Dilemma, the difficulty in achieving effective translation of basic mechanistic biomedical knowledge into effective therapeutics, is the greatest challenge in biomedical research. Nowhere is this more apparent than in understanding and manipulating the acute inflammatory response in the settings of sepsis, trauma/hemorrhage, wound healing, and related processes. The burgeoning fields of complex systems analysis and computational biology offer researchers a pathway towards addressing the Translational Dilemma. Complex Systems and Computational Biology Approaches to Acute Inflammation presents the current state of the art of multi-disciplinary and systems-oriented research approaches to complex diseases arising from and driven by the acute inflammatory response. The chapters in this volume provide an introduction to different types of computational modeling, and how these methods can be applied to specific inflammatory diseases, with a focus on providing readers with a roadmap for integrating advanced mathematical and computational techniques with traditional experimental methods. By presenting the role of computational modeling as an integrated component of the research process, Complex Systems and Computational Biology Approaches to Acute Inflammation offers a window into the future of biomedical research.
650 0 _aLife sciences.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aBiological models.
650 1 4 _aLife Sciences.
650 2 4 _aSystems Biology.
650 2 4 _aImmunology.
650 2 4 _aBiomedicine general.
700 1 _aAn, Gary.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461480075
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-8008-2
912 _aZDB-2-SBL
999 _c96018
_d96018