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008 130913s2013 xxu| s |||| 0|eng d
020 _a9781461479536
_9978-1-4614-7953-6
024 7 _a10.1007/978-1-4614-7953-6
_2doi
050 4 _aQR180-189.5
072 7 _aMJCM
_2bicssc
072 7 _aMED044000
_2bisacsh
082 0 4 _a616.079
_223
100 1 _aYamamura, Takashi.
_eeditor.
245 1 0 _aMultiple Sclerosis Immunology
_h[electronic resource] :
_bA Foundation for Current and Future Treatments /
_cedited by Takashi Yamamura, Bruno Gran.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXVII, 461 p. 46 illus., 38 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aTh17 cells in autoimmune inflammation and demyelination in the central nervous system -- Regulatory T cells in MS -- T-bet: A critical regulator of encephalitogenic T Cells -- Antigen-presenting cells in the Central Nervous System -- The role of B cells in multiple sclerosis -- Diet, gut flora and multiple sclerosis: current research and future perspectives -- GM-CSF in autoimmune inflammation of the central nervous system -- The role of Toll-like receptors in multiple sclerosis and experimental autoimmune encephalomyelitis -- Macrophages and microglia in experimental autoimmune encephalomyelitis and multiple sclerosis -- Genetics of multiple sclerosis -- Gene expression profiling and pathway analysis for identification of molecular targets in MS -- Systems biology for the study of multiple sclerosis -- Checkpoints in the development of pathogenic and regulatory T cells in Experimental Autoimmune Encephalomyelitis—a basis for current future interventions in MS -- Modeling MS in non-human primates -- A novel concept of treatment in MS: targeting both oligodendrocyte death and inflammatory processes by inhibiting poly (ADP-Ribose) polymerase -- Association of MS with other autoimmune diseases -- Current and future treatments of Multiple Sclerosis -- Targeting CD52 for the treatment of Multiple Sclerosis -- Haematopoietic stem cells for the treatment of MS -- Mesenchymal stem cells for the treatment of Multiple Sclerosis.
520 _aThe availability of powerful genome-wide association study technology, during the last five years, has shown that most of the “new” MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function.  Multiple Sclerosis Immunology  looks at MS immunology as the basis for the present and—even more—the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that “translation” is real and not just virtual.
650 0 _aMedicine.
650 0 _aMedical genetics.
650 0 _aImmunology.
650 1 4 _aBiomedicine.
650 2 4 _aImmunology.
650 2 4 _aGene Function.
650 2 4 _aMolecular Medicine.
700 1 _aGran, Bruno.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461479529
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-7953-6
912 _aZDB-2-SBL
999 _c96008
_d96008