000			03106nam a22004695i 4500
001			978-1-4614-7855-3
003			DE-He213
005			20140220082830.0
007			cr nn 008mamaa
008			130829s2013 xxu| s |||| 0|eng d
020			_a9781461478553 _9978-1-4614-7855-3
024	7		_a10.1007/978-1-4614-7855-3 _2doi
050		4	_aQD431-431.7
072		7	_aPSBC _2bicssc
072		7	_aSCI007000 _2bisacsh
082	0	4	_a572.6 _223
100	1		_aBence, Kendra K. _eeditor.
245	1	0	_aProtein Tyrosine Phosphatase Control of Metabolism _h[electronic resource] / _cedited by Kendra K. Bence.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXI, 273 p. 34 illus., 24 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aRedox Regulation of PTPs in Metabolism: Focus on Assays -- Quantitative Modeling of PTPs and Implications for Studying Metabolic Signaling -- Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism -- PTP1B and TCPTP in CNS Signaling and Energy Balance -- PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress -- Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling -- PTP1B in Obesity-Related Cardiovascular Runction -- Role of SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism -- Metabolic Effects of Neural and Pancreatic SHP2 -- Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism -- The Role of LMPTP in the Metabolic Syndrome -- Mitogen-Activated Protein Kinase Phosphatases in Metabolism -- Glycogen Metabolism and Lafora Disease -- Index.
520			_aTyrosine phosphorylation is a rapid and reversible protein modification catalyzed by the yin and yang activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs).  A multitude of PTPs have been implicated in human disease, with a growing number of PTPs now known to play major roles in prevalent metabolic diseases including obesity and type 2 diabetes.  Recent studies into PTP function in the context of metabolism highlight the importance of understanding the specific substrates and binding partners of these enzymes, the regulation of PTP activity, and the cell/tissue specificity of PTP functions.  This volume contains chapters which highlight many aspects of PTP function in the context of metabolism.
650		0	_aLife sciences.
650		0	_aMedicine.
650		0	_aEndocrinology.
650		0	_aBiochemistry.
650	1	4	_aLife Sciences.
650	2	4	_aProtein Science.
650	2	4	_aEndocrinology.
650	2	4	_aBiochemistry, general.
650	2	4	_aBiomedicine general.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461478546
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-7855-3
912			_aZDB-2-SBL
999			_c95997 _d95997