| 000 | 02714nam a22004575i 4500 | ||
|---|---|---|---|
| 001 | 978-1-4614-7759-4 | ||
| 003 | DE-He213 | ||
| 005 | 20140220082830.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 130706s2013 xxu| s |||| 0|eng d | ||
| 020 |
_a9781461477594 _9978-1-4614-7759-4 |
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| 024 | 7 |
_a10.1007/978-1-4614-7759-4 _2doi |
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| 050 | 4 | _aRC321-580 | |
| 072 | 7 |
_aPSAN _2bicssc |
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| 072 | 7 |
_aMED057000 _2bisacsh |
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| 082 | 0 | 4 |
_a612.8 _223 |
| 100 | 1 |
_aBorisova, Tatiana. _eauthor. |
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| 245 | 1 | 0 |
_aCholesterol and Presynaptic Glutamate Transport in the Brain _h[electronic resource] / _cby Tatiana Borisova. |
| 264 | 1 |
_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013. |
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| 300 |
_aXVI, 75 p. 32 illus., 11 illus. in color. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_aonline resource _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 490 | 1 |
_aSpringerBriefs in Neuroscience, _x2191-558X ; _v12 |
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| 505 | 0 | _aPresynaptic glutamate transport in the brain -- Cholesterol and its role in synaptic transmission -- Effects of cholesterol-depleting agent methyl-b-cyclodextrin (MbCD) on the functional state of brain nerve terminals -- The extracellular level and uptake of glutamate in cholesterol-deficient nerve terminals -- Unstimulated and exocytotic glutamate release from cholesterol-deficient nerve terminals -- Neuroprotection by lowering cholesterol. | |
| 520 | _aGlutamate is the primary excitatory neurotransmitter in the CNS and disturbances in glutamate transport contribute to a number of neurological and neurodegenerative disorders. Appropriate levels of cholesterol are very important for the proper functioning of glutamate transport while unbalanced levels of cholesterol have been implicated in the pathogenesis of disorders such as stroke, ischemia, traumatic brain injury, and neurotoxicity. In the proposed book, the author presents data from the literature and from her own lab to address the extent to and way in which membrane cholesterol modulates presynaptic glutamate transport and whether lowering the level of cholesterol available can offer some neuroprotective benefits. | ||
| 650 | 0 | _aMedicine. | |
| 650 | 0 | _aNeurosciences. | |
| 650 | 0 | _aNeurochemistry. | |
| 650 | 1 | 4 | _aBiomedicine. |
| 650 | 2 | 4 | _aNeurosciences. |
| 650 | 2 | 4 | _aNeurochemistry. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9781461477587 |
| 830 | 0 |
_aSpringerBriefs in Neuroscience, _x2191-558X ; _v12 |
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| 856 | 4 | 0 | _uhttp://dx.doi.org/10.1007/978-1-4614-7759-4 |
| 912 | _aZDB-2-SBL | ||
| 999 |
_c95977 _d95977 |
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