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001 978-1-4614-7690-0
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008 130930s2013 xxu| s |||| 0|eng d
020 _a9781461476900
_9978-1-4614-7690-0
024 7 _a10.1007/978-1-4614-7690-0
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aSelvarajoo, Kumar.
_eauthor.
245 1 0 _aImmuno Systems Biology
_h[electronic resource] :
_bA macroscopic approach for immune cell signaling /
_cby Kumar Selvarajoo.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aIX, 146 p. 69 illus., 61 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSystems Biology,
_x2191-222X ;
_v3
505 0 _aPreface -- Systems biology of population cell response -- Perturbation-response approach for biological network analysis -- Basics of the mammalian immune system -- Inferring novel features of the TLR4 pathways -- Signaling Flux Redistribution -- Investigating the TLR3 signaling dynamics -- Understanding TNFR1 signaling dynamics -- TRAIL signaling in cancer -- Stochasticity and variability: insights from single cell dynamics -- Investigating single cell stochasticity in TRAIL signaling -- The distinction between single cell and population dynamics -- Finding chaos in biology -- Concluding remarks -- Index.
520 _aTechnological advances of modern biology have generated high volumes of ‘omics’ data. The natural precedence has been to put the complex information together, so that it will lead to spectacular scientific discoveries and medical breakthroughs. In this light, tremendous efforts worldwide are reshaping biological research by integrating with information science. Despite the ‘systems biology’ efforts, for major illnesses, such as proinflammatory diseases and cancer, there is clear clinical evidence that even the most current therapies, at best, control transient response and subdue to the robust adaptability of the disease state. Hence, there is a need for system-levels understanding of bio-complexity. Kumar Selvarajoo brings attention to fundamental questions governing sophisticated behaviors of the mammalian immune system. To tackle some of the complex issues, the book introduces perturbation-response approach, using the law of physics (mass flow conservation), as a means to interpret the dynamic response of major proinflammatory pathways of the immune and cancer cells. Overall, the book provides an illustrated journey that explains biological cell signaling in simple terms.
650 0 _aMedicine.
650 0 _aImmunology.
650 0 _aBioinformatics.
650 0 _aBiological models.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aSystems Biology.
650 2 4 _aBioinformatics.
650 2 4 _aComputational Biology/Bioinformatics.
650 2 4 _aImmunology.
650 2 4 _aCell Biology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461474593
830 0 _aSystems Biology,
_x2191-222X ;
_v3
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-7690-0
912 _aZDB-2-SBL
999 _c95964
_d95964