000			03731nam a22005055i 4500
001			978-1-4614-7678-8
003			DE-He213
005			20140220082830.0
007			cr nn 008mamaa
008			130808s2013 xxu| s |||| 0|eng d
020			_a9781461476788 _9978-1-4614-7678-8
024	7		_a10.1007/978-1-4614-7678-8 _2doi
050		4	_aQH505
072		7	_aPHVN _2bicssc
072		7	_aPHVD _2bicssc
072		7	_aSCI009000 _2bisacsh
082	0	4	_a571.4 _223
100	1		_aSolaro, R. John. _eeditor.
245	1	0	_aBiophysics of the Failing Heart _h[electronic resource] : _bPhysics and Biology of Heart Muscle / _cedited by R. John Solaro, Jil C. Tardiff.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aVI, 253 p. 30 illus., 26 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aBiological and Medical Physics, Biomedical Engineering, _x1618-7210
505	0		_aChapter 1 Introduction to the Biophysics of the Failing Heart -- Chapter 2 Sarcoplasmic reticulum Ca homeostasis and Heart Failure -- Chapter 3 Ca-homeostasis and Heart Failure: Focus on the Biophysics of Surface Membrane Ca-Fluxes -- Chapter 4 Biophysics of Membrane Currents in Heart Failure -- Chapter 5 Biophysical Mechanisms for the Metabolic Component of Impaired Heart Function -- Chapter 6 Cytoskeletal Nuclear Links in the Cardiomyocyte -- Chapter 7 Biophysical Forces Modulate the Costamere and Z-Disc -- Chapter 8 Heart failure- the final frontier for biophysics in cardiovascular medicine? -- Chapter 9 Arrhythmogenesis, Heart Failure, and the Biophysics of Z-band Protein Networks -- Chapter 10 Biophysics of Titin in Cardiac Health and Disease -- Chapter 11 Sarcomeres and the Biophysics of Heart Failure -- Index.
520			_aBiophysics of the Failing Heart considers major biophysical mechanisms for why hearts responding to stressors enter into maladaptive processes, eventually leading to an inability of the heart to respond efficiently to hemodynamic loads--especially during exercise. The book describes biophysical techniques that have been applied to determine the triggers for the heart failure process, as well as the mechanisms for sustaining the disorders. These techniques include measurements of active and passive mechanical properties and hemodynamics at levels of organization ranging from molecules to hearts beating in situ. Biophysical concepts and approaches are also applied to determination of signaling and signal transduction, energetics, ionic currents, transport processes, electro-chemical and chemo-mechanical coupling. Modern research approaches and clinical understanding of heart failure demands integration of multiple aspects of the disorders. By its emphasis on biophysical aspects of a prevalent clinical condition, this monograph is unique in its perspective and focus, and will be of value to clinicians and researchers at all levels.
650		0	_aPhysics.
650		0	_aCardiology.
650		0	_aBiomedical engineering.
650	1	4	_aPhysics.
650	2	4	_aBiophysics and Biological Physics.
650	2	4	_aCardiology.
650	2	4	_aMedical and Radiation Physics.
650	2	4	_aBiomedical Engineering.
700	1		_aTardiff, Jil C. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461476771
830		0	_aBiological and Medical Physics, Biomedical Engineering, _x1618-7210
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-7678-8
912			_aZDB-2-PHA
999			_c95960 _d95960