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001			978-1-4614-7645-0
003			DE-He213
005			20140220082830.0
007			cr nn 008mamaa
008			130804s2013 xxu| s |||| 0|eng d
020			_a9781461476450 _9978-1-4614-7645-0
024	7		_a10.1007/978-1-4614-7645-0 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aWu, Wei. _eeditor.
245	1	0	_aNext Generation Sequencing in Cancer Research _h[electronic resource] : _bVolume 1: Decoding the Cancer Genome / _cedited by Wei Wu, Hani Choudhry.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXII, 383 p. 73 illus., 59 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction: next generation sequencing technology and cancer research -- The majority of total nuclear-encoded non-ribosomal RNA in a human cell is ‘dark matter’ unannotated RNA -- Total RNA-seq of breast cancer in hypoxia -- Altered antisense-to-sense transcript ratios in breast cancer -- Identification of piRNAs in Hela cells by massive parallel sequencing -- Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia -- Whole-Exome Sequencing Identifies FAM20A Mutations as a Cause of Amelogenesis Imperfecta and Gingival Hyperplasia Syndrome -- Whole-exome sequencing in CIC and IDH1/2 contributing to human oligodendroglioma -- Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing -- Tumour evolution inferred by single-cell sequencing -- Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq -- Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNASeq analysis -- Whole genome DNA methylation analysis based on high throughput sequencing technology -- Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors -- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq -- MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA action -- Genome-wide identification of polycomb-associated RNAs by RIP-seq -- Single-molecule sequencing: sequence methods to enable accurate quantisation -- Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells -- Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA -- The genome information process for cancer research: the challenge and perspective -- Index.
520			_aNext Generation Sequencing (NGS) technology has placed important milestones in the life science and changed the direction in biomedical science inclucing cancer. Scientists around the world are attempting to find the root cause of cancer and they are looking for more direct and effective means to cure cancer. This journey to conquer cancer is more optimistic now with the unfolding of the cancer genome. This book focuses on the application of various NGS in the frontier cancer genome research. The 18 chapters in this volume have been written by scientists with many outstanding contributions in their area and the join effort has created comprehensive insightful view on (1) Overview of next generation sequencing technology in cancer genome research (2) Genome regulation and targeted sequencing in cancer (3) RNA transcriptome (coding and non-coding) in cancer genome (4)The challenges of computational biology for cancer genome study. This book is a state-of-the-art reference to all scientific researchers and onologists who are interested in the understanding of the cancer initiatome at whole genome scale and to those are keen to translate the ‘base pairs to bedside’ for better management of cancer patients in the era of personalized medicine.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aHuman genetics.
650		0	_aBioinformatics.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aBioinformatics.
650	2	4	_aHuman Genetics.
650	2	4	_aBiomedicine general.
700	1		_aChoudhry, Hani. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461476443
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-7645-0
912			_aZDB-2-SBL
999			_c95954 _d95954