000 02976nam a22004815i 4500
001 978-1-4614-6886-8
003 DE-He213
005 20140220082827.0
007 cr nn 008mamaa
008 130402s2013 xxu| s |||| 0|eng d
020 _a9781461468868
_9978-1-4614-6886-8
024 7 _a10.1007/978-1-4614-6886-8
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aFrappier, Lori.
_eauthor.
245 1 0 _aEBNA1 and Epstein-Barr Virus Associated Tumours
_h[electronic resource] /
_cby Lori Frappier.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aVII, 43 p. 5 illus., 4 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSpringerBriefs in Cancer Research ;
_v3
505 0 _a.-Introduction. -- Roles of EBNA1 at EBV Episomes. -- EBNA1-DNA Interactions. -- EBNA1 Contributions to EBV-associated Tumours. -- Cellular Effects of EBNA1. -- Conclusion .
520 _aThis SpringerBrief is comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers.   EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. This book offers a current synopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions is also discussed as well as implications for tumourigenesis. In addition, the cellular effects of EBNA1 will be reviewed, including how EBNA1 manipulates specific cellular proteins and relationships to EBV-associated lymphomas and carcinomas.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aMicrobiology.
650 0 _aMedical virology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aVirology.
650 2 4 _aMedical Microbiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461468851
830 0 _aSpringerBriefs in Cancer Research ;
_v3
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-6886-8
912 _aZDB-2-SBL
999 _c95785
_d95785