000			03689nam a22005295i 4500
001			978-1-4614-6828-8
003			DE-He213
005			20140220082826.0
007			cr nn 008mamaa
008			130509s2013 xxu| s |||| 0|eng d
020			_a9781461468288 _9978-1-4614-6828-8
024	7		_a10.1007/978-1-4614-6828-8 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aTindall, Donald J. _eeditor.
245	1	0	_aProstate Cancer _h[electronic resource] : _bBiochemistry, Molecular Biology and Genetics / _cedited by Donald J. Tindall.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aXII, 522 p. 41 illus., 38 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProtein Reviews ; _v16
505	0		_aPreface -- Section 1: Cell Biology -- Stem Cells in the Normal and Malignant Prostate -- Role of Reactive Stroma in Prostate Cancer -- The Role of Cholesterol in Prostate Cancer -- Section 2: Genetics: PTEN in Prostate Cancer -- ETS fusion genes in prostate cancer -- Section 3: Cell Signaling -- Signaling Mechanisms of Vav3, a Guanine Nucleotide Exchange Factor and Androgen Receptor Coactivator, in Physiology and Prostate Cancer Progression -- Transforming Growth Factor-beta (TGF-b) in Prostate Cancer -- The p38 MAPK Pathway in Prostate Cancer -- NF-kappaB2/p52 in Prostate Cancer -- The functional role of DAB2IP, a homeostatic factor, in prostate cancer -- Tyrosine Kinases in Prostate Cancer -- Human prostatic acid phosphatase in prostate carcinogenesis -- Section 4: Hormonal -- Truncated Androgen Receptor Splice Variants in Prostate Cancer -- Biology and Clinical Relevance of Estrogen Receptors in Prostate Cancer -- Vitamin D and Prostate Cancer -- HDAC6 regulation of androgen signaling in prostate cancer -- Beyond the cell cycle: Implications of D-type cyclin deregulation in Pca -- Section 5: Cell Death -- Role of Par- in Prostate Cancer -- Autophagy and Prostate Cancer Therapeutics -- Index.
520			_aProstate cancer is the most frequently diagnosed non-cutaneous malignancy in men, and the second leading cause of male cancer-related mortality in the United States.  The last decade has seen unprecedented progress in the detection, prognosis, treatment and prevention of prostate cancer. These advances have been driven largely by an increased understanding of the underlying biochemistry, molecular biology and genetics of the disease. New cell and animal models have been developed that recapitulate the natural progression of prostate cancer. New technologies have allowed scientists to view in detail the genomic, proteomic, metabolomics and other –omic universe of cancer cells and tissues. This has resulted in a greater understanding of the pathophysiology of the disease.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aBiochemistry.
650		0	_aCell receptors.
650		0	_aCytology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aMedical Biochemistry.
650	2	4	_aCell Biology.
650	2	4	_aProtein Science.
650	2	4	_aReceptors.
650	2	4	_aBiological Networks, Systems Biology.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461468271
830		0	_aProtein Reviews ; _v16
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-6828-8
912			_aZDB-2-SBL
999			_c95768 _d95768