000 03222nam a22004935i 4500
001 978-1-4614-6561-4
003 DE-He213
005 20140220082825.0
007 cr nn 008mamaa
008 130330s2013 xxu| s |||| 0|eng d
020 _a9781461465614
_9978-1-4614-6561-4
024 7 _a10.1007/978-1-4614-6561-4
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aWang, Hong-Gang.
_eeditor.
245 1 0 _aAutophagy and Cancer
_h[electronic resource] /
_cedited by Hong-Gang Wang.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXI, 261 p. 33 illus., 29 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCurrent Cancer Research ;
_v8
505 0 _aPreface -- Historical Overview of Autophagy -- The Core Molecular Machinery of Autophagosome Formation -- The origin of autophagosomes: The beginning of an end -- Signal Transduction Regulation of Autophagy -- Role of Autophagy in Tumorigenesis -- Selective autophagy and cancer -- Oncogenes and tumor suppressor genes in autophagy -- Autophagy and Immunity -- Autophagy and the Tumor Microenvironment -- Autophagy and Cancer Therapy -- The Crosstalk between Apoptosis & Autophagy -- Autophagy and Cancer Drug Discovery -- Index.
520 _aThis book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction regulation of autophagy. The next chapters deal with the complex relationship between autophagy and tumorigenesis through in-depth discussions of how autophagy influences cell survival, apoptosis, inflammation, immunity, tumor microenvironment, metabolic stress, DNA damage, and genomic instability. The remaining chapters discuss how autophagy affects cancer cell response to therapy and how to best modulate autophagy for therapeutic benefit - what to target and how to target. We hope that this monograph will be an invaluable reference source for professionals, students, postdoctoral fellows, and senior scientists working in the fields of autophagy and cancer.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aHuman physiology.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aMolecular Medicine.
650 2 4 _aCell Biology.
650 2 4 _aHuman Physiology.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461465607
830 0 _aCurrent Cancer Research ;
_v8
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-6561-4
912 _aZDB-2-SME
999 _c95703
_d95703