000 02997nam a22004455i 4500
001 978-1-4614-6498-3
003 DE-He213
005 20140220082825.0
007 cr nn 008mamaa
008 130413s2013 xxu| s |||| 0|eng d
020 _a9781461464983
_9978-1-4614-6498-3
024 7 _a10.1007/978-1-4614-6498-3
_2doi
050 4 _aRC261-271
072 7 _aMJCL
_2bicssc
072 7 _aMED062000
_2bisacsh
082 0 4 _a614.5999
_223
100 1 _aCramer, Scott D.
_eeditor.
245 1 0 _aStem Cells and Prostate Cancer
_h[electronic resource] /
_cedited by Scott D. Cramer.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aVII, 182 p. 21 illus., 18 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aPreface -- Stem Cells and Prostate Development -- Isolation and Characterization of Prostate Stem Cells -- Prostate tumor initiating cells -- TIC Markers and methods of characterization -- Genetic Control of Self Renewal of the TIC -- Therapeutic targeting of the prostate TIC.- The prostate stem cell niche.- Tumor stroma control of the prostate TIC.- Targeting the prostate stem cell for chemoprevention.- Stem cell models for functional validation of prostate cancer genes -- Index .
520 _aRecent evidence demonstrates that normal prostate tissue contains stem cells.  There is also accumulating evidence that prostate cancer contains a population of cells with stem cell-like characteristics referred to as cancer stem cells, or tumor initiating cells.  Both the normal prostate stem cell and cancer stem cell populations have important implications for the generation, therapeutic targeting, and prevention of prostate cancer.  This book will explore the role of stem cells in normal prostate development and prostate cancer, methods for isolation and characterization of normal prostate stem cells and prostate tumor initiating cells, the functional relationship between normal stem cells and prostate tumor initiating cells, the relationship of prostate cancer genetics and self-renewal and differentiation, the prostate stem cell as a target for therapeutics and prevention, and the utility of stem cells for prostate cancer models.  This book synthesizes these concepts and more into a single volume accessible to basic and translational researchers in prostate cancer and beyond.
650 0 _aMedicine.
650 0 _aOncology.
650 0 _aCytology.
650 1 4 _aBiomedicine.
650 2 4 _aCancer Research.
650 2 4 _aCell Biology.
650 2 4 _aBiomedicine general.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461464976
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-6498-3
912 _aZDB-2-SBL
999 _c95685
_d95685