000			03703nam a22004815i 4500
001			978-1-4614-6220-0
003			DE-He213
005			20140220082823.0
007			cr nn 008mamaa
008			130321s2013 xxu| s |||| 0|eng d
020			_a9781461462200 _9978-1-4614-6220-0
024	7		_a10.1007/978-1-4614-6220-0 _2doi
050		4	_aRC261-271
072		7	_aMJCL _2bicssc
072		7	_aMED062000 _2bisacsh
082	0	4	_a614.5999 _223
100	1		_aOren, Moshe. _eeditor.
245	1	4	_aThe Hippo Signaling Pathway and Cancer _h[electronic resource] / _cedited by Moshe Oren, Yael Aylon.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2013.
300			_aVI, 354 p. 46 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aIntroduction -- Merlin and Angiomotin in Hippo-Yap signaling -- MST1/2 and other upstream signaling that affect Hippo pathway function -- YAP1 uses its modular protein domains and conserved sequence motifs to orchestrate diverse repertoires of signaling -- Regulation of YAP and TAZ transcription co-activators -- Regulation of YAP and TAZ by epithelial plasticity -- Hippo pathway and apoptosis -- YAP and p73: a matter of mutual specificity in tumour suppression -- The c-Abl/YAP/p73 apoptotic module and the Hippo pathway -- Hippo in cell cycle and mitosis -- Hippo and mouse models for cancer -- Roles of Hippo signaling during mouse embryogenesis -- Hippo Signaling and stem cells -- Hippo signaling and organ size control -- Hippo signaling in heart development -- Cell competition and the Hippo pathway -- Non-canonical roles from the Hippo pathway -- Index.
520			_aThe Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorgenesis. This volume presents virtually all aspects of tumor biology because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Rho, Wnt, TGFbeta and p53. Hippo signaling is not solely involved in regulating “classic” tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.
650		0	_aMedicine.
650		0	_aOncology.
650		0	_aMicrobiology.
650		0	_aCytology.
650	1	4	_aBiomedicine.
650	2	4	_aCancer Research.
650	2	4	_aCell Biology.
650	2	4	_aMedical Microbiology.
650	2	4	_aBiomedicine general.
700	1		_aAylon, Yael. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461462194
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-6220-0
912			_aZDB-2-SBL
999			_c95614 _d95614