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001 978-1-4614-6199-9
003 DE-He213
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007 cr nn 008mamaa
008 130403s2013 xxu| s |||| 0|eng d
020 _a9781461461999
_9978-1-4614-6199-9
024 7 _a10.1007/978-1-4614-6199-9
_2doi
050 4 _aR-RZ
072 7 _aMBGR
_2bicssc
072 7 _aMED000000
_2bisacsh
082 0 4 _a610
_223
100 1 _aKauffman, Alexander S.
_eeditor.
245 1 0 _aKisspeptin Signaling in Reproductive Biology
_h[electronic resource] /
_cedited by Alexander S. Kauffman, Jeremy T. Smith.
264 1 _aNew York, NY :
_bSpringer New York :
_bImprint: Springer,
_c2013.
300 _aXII, 514 p. 100 illus., 58 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v784
505 0 _aPart One: Kisspeptin Signaling in vivo and in vitro -- Kisspeptin: Past, Present and Prologue -- Structure, Synthesis, and Phylogeny of Kisspeptin and its Receptor -- Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects -- The Effects of Kisspeptin on Gonadotropin Release in Non-Human Mammals -- Effects of Kisspeptin on Hormone Secretion in Humans -- Kisspeptin Excitation of GnRH Neurons -- Molecular Biology of the Kisspeptin Receptor: Signaling, Function, and Mutations -- Kisspeptin Antagonists -- Kisspeptin and Clinical Disorders -- Beyond the GnRH Axis: Kisspeptin Regulation of the Oxytocin System in Pregnancy and Lactation -- Part Two: Development and Regulation of Kisspeptin Neurons -- The Development of Kisspeptin Circuits in the Mammalian Brain -- Kisspeptin and Puberty in Mammals -- Sex Steroid Regulation of Kisspeptin Circuits -- Kisspeptin and GnRH Pulse Generation -- Interactions between Kisspeptins and Neurokinin B -- Electrophysiology of Kisspeptin Neurons -- Metabolic Regulation of Kisspeptin -- Circadian Regulation of Kisspeptin in Female Reproductive Functioning -- Kisspeptin and Seasonality of Reproduction -- Stress Regulation of Kisspeptin in the Modulation of Reproductive Function -- Effects of Environmental Endocrine Disruptors and Phytoestrogens on the Kisspeptin System -- Model Systems for Studying Kisspeptin Signaling: Mice and Cells -- Index.
520 _aKisspeptin has been shown to be both necessary and sufficient for activation of the reproductive axis, during puberty and later in adulthood.  This makes kisspeptin a fundamental component of the reproductive axis. Kisspeptin has been deemed the single most potent stimulator of GnRH neurons yet known.  The importance of kisspeptin has been documented in humans as well as non-human animal models, ranging from monkeys, sheep, and rodents to numerous fish species, thus signifying a highly conserved nature of its reproductive function.  Importantly, kisspeptin neurons seem to mediate many of the regulatory effects of other signals, whether they are metabolic, circadian, hormonal, or stress. This places kisspeptin neurons in a unique position to be key nodal points and conduits for conveying numerous endogenous and exogenous signals to the reproductive axis.
650 0 _aMedicine.
650 0 _aNeurosciences.
650 0 _aEndocrinology.
650 0 _aReproductive Medicine.
650 1 4 _aBiomedicine.
650 2 4 _aBiomedicine general.
650 2 4 _aEndocrinology.
650 2 4 _aReproductive Medicine.
650 2 4 _aNeurosciences.
700 1 _aSmith, Jeremy T.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9781461461982
830 0 _aAdvances in Experimental Medicine and Biology,
_x0065-2598 ;
_v784
856 4 0 _uhttp://dx.doi.org/10.1007/978-1-4614-6199-9
912 _aZDB-2-SBL
999 _c95607
_d95607