000			03291nam a22004815i 4500
001			978-1-4614-6144-9
003			DE-He213
005			20140220082823.0
007			cr nn 008mamaa
008			130217s2013 xxu| s |||| 0|eng d
020			_a9781461461449 _9978-1-4614-6144-9
024	7		_a10.1007/978-1-4614-6144-9 _2doi
050		4	_aR-RZ
072		7	_aMBGR _2bicssc
072		7	_aMED000000 _2bisacsh
082	0	4	_a610 _223
100	1		_aIaizzo, Paul A. _eeditor.
245	1	0	_aHeart Valves _h[electronic resource] : _bFrom Design to Clinical Implantation / _cedited by Paul A. Iaizzo, Richard W. Bianco, Alexander J. Hill, James D. St. Louis.
264		1	_aBoston, MA : _bSpringer US : _bImprint: Springer, _c2013.
300			_aXI, 429 p. 170 illus., 116 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_aonline resource _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aPart I - ANATOMY, PHYSIOLOGY, CONGENITAL DEFECTS, and DISEASE -- The anatomy and function of the atrioventricular valves -- The anatomy and function of the semilunar valves -- Congenital heart defects that include cardiac valve abnormalities -- Acquired valve disease and processes -- Part II - VALVE REPAIR AND REPLACEMENT -- History of heart valve repair -- Heart valve disease -- Advanced 3D imaging and transcatheter valve repair/ implantation -- Transcatheter mitral repair and replacement -- Percutaneous pulmonary valve implantation: the first transcatheter valve -- Transcatheter aortic valve implantation -- Tissue engineered heart valves -- Part III - TESTING AND REGULATORY ISSUES -- In vitro testing of heart valve substitutes -- Numerical methods for design and evaluation of prosthetic heart valves -- Animal models for cardiac valve research -- The use of isolated heart models and anatomic specimens as means to enhance the design and testing of cardiac valve therapies -- Successful development and regulatory approval of replacement cardiac valves -- Clinical trial requirements for cardiac valves -- Index.
520			_aCardiovascular disease is the major cause of morbidity and mortality worldwide. While the past 40 years have brought major progress in cardiac valve repair and replacement, there remain large patient populations that do not receive such therapies. This, in turn, implies a great need for future basic, applied, and clinical research and, ultimately, therapeutic developments. Heart Valves is a state-of-the-art handbook dedicated to: 1) cardiac valve anatomy, 2) models for testing and research methods; 3) clinical trials; and 4) clinical needs and applications.
650		0	_aMedicine.
650		0	_aCardiology.
650		0	_aHeart _xSurgery.
650	1	4	_aBiomedicine.
650	2	4	_aBiomedicine general.
650	2	4	_aCardiology.
650	2	4	_aCardiac Surgery.
700	1		_aBianco, Richard W. _eeditor.
700	1		_aHill, Alexander J. _eeditor.
700	1		_aSt. Louis, James D. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9781461461432
856	4	0	_uhttp://dx.doi.org/10.1007/978-1-4614-6144-9
912			_aZDB-2-SBL
999			_c95594 _d95594